PC39-1 mAb sequence alignment.

<p>Alignments of HC (top) and LC (bottom) of the PC39-1 mAbs, relative to the UCA/iGL sequences, with regions indicated and colored by residue, according to the given key, showing accumulated mutations in the mAbs over time. mAb names are colored by antibody CDRH1 insertion and ordered by isol...

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Main Author:	Collin Joyce (16469212) (author)
Other Authors:	Sasha Murrell (16469215) (author), Ben Murrell (151760) (author), Oluwarotimi Omorodion (3287124) (author), Lorena S. Ver (16469218) (author), Nancy Carrico (16469221) (author), Raiza Bastidas (16469224) (author), Rebecca Nedellec (348332) (author), Michael Bick (16469227) (author), Jordan Woehl (16469230) (author), Fangzhu Zhao (12476373) (author), Alison Burns (12476367) (author), Shawn Barman (12476370) (author), Michael Appel (16469233) (author), Alejandra Ramos (386538) (author), Lalinda Wickramasinghe (845747) (author), Kemal Eren (6083528) (author), Thomas Vollbrecht (492146) (author), Davey M. Smith (12883985) (author), Sergei L. Kosakovsky Pond (8321352) (author), Ryan McBride (409526) (author), Charli Worth (7326596) (author), Facundo Batista (9104558) (author), Devin Sok (409518) (author), Pascal Poignard (244468) (author), Bryan Briney (488298) (author), Ian A. Wilson (113692) (author), Elise Landais (845745) (author), Dennis R. Burton (106420) (author)
Published:	2023
Subjects:	Biophysics Evolutionary Biology Ecology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified secreting cell compartments na &# 239 inform vaccine design focusing ab responses arms &# 8221 11 amino acids multiple independent insertions two founder viruses single antibody position potent bnab lineage founder viruses including insertions virus separated unusual features subtype c predominantly atypical potential enhancer neutralization breadth longitudinal studies indels ). humoral system help stabilize findings suggest extensive recombination evolved independently early exposure antigen pressure
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author	Collin Joyce (16469212)
author2	Sasha Murrell (16469215) Ben Murrell (151760) Oluwarotimi Omorodion (3287124) Lorena S. Ver (16469218) Nancy Carrico (16469221) Raiza Bastidas (16469224) Rebecca Nedellec (348332) Michael Bick (16469227) Jordan Woehl (16469230) Fangzhu Zhao (12476373) Alison Burns (12476367) Shawn Barman (12476370) Michael Appel (16469233) Alejandra Ramos (386538) Lalinda Wickramasinghe (845747) Kemal Eren (6083528) Thomas Vollbrecht (492146) Davey M. Smith (12883985) Sergei L. Kosakovsky Pond (8321352) Ryan McBride (409526) Charli Worth (7326596) Facundo Batista (9104558) Devin Sok (409518) Pascal Poignard (244468) Bryan Briney (488298) Ian A. Wilson (113692) Elise Landais (845745) Dennis R. Burton (106420)
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author
author_facet	Collin Joyce (16469212) Sasha Murrell (16469215) Ben Murrell (151760) Oluwarotimi Omorodion (3287124) Lorena S. Ver (16469218) Nancy Carrico (16469221) Raiza Bastidas (16469224) Rebecca Nedellec (348332) Michael Bick (16469227) Jordan Woehl (16469230) Fangzhu Zhao (12476373) Alison Burns (12476367) Shawn Barman (12476370) Michael Appel (16469233) Alejandra Ramos (386538) Lalinda Wickramasinghe (845747) Kemal Eren (6083528) Thomas Vollbrecht (492146) Davey M. Smith (12883985) Sergei L. Kosakovsky Pond (8321352) Ryan McBride (409526) Charli Worth (7326596) Facundo Batista (9104558) Devin Sok (409518) Pascal Poignard (244468) Bryan Briney (488298) Ian A. Wilson (113692) Elise Landais (845745) Dennis R. Burton (106420)
author_role	author
dc.creator.none.fl_str_mv	Collin Joyce (16469212) Sasha Murrell (16469215) Ben Murrell (151760) Oluwarotimi Omorodion (3287124) Lorena S. Ver (16469218) Nancy Carrico (16469221) Raiza Bastidas (16469224) Rebecca Nedellec (348332) Michael Bick (16469227) Jordan Woehl (16469230) Fangzhu Zhao (12476373) Alison Burns (12476367) Shawn Barman (12476370) Michael Appel (16469233) Alejandra Ramos (386538) Lalinda Wickramasinghe (845747) Kemal Eren (6083528) Thomas Vollbrecht (492146) Davey M. Smith (12883985) Sergei L. Kosakovsky Pond (8321352) Ryan McBride (409526) Charli Worth (7326596) Facundo Batista (9104558) Devin Sok (409518) Pascal Poignard (244468) Bryan Briney (488298) Ian A. Wilson (113692) Elise Landais (845745) Dennis R. Burton (106420)
dc.date.none.fl_str_mv	2023-06-29T17:44:06Z
dc.identifier.none.fl_str_mv	10.1371/journal.ppat.1011416.s002
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/PC39-1_mAb_sequence_alignment_/23601589
dc.rights.none.fl_str_mv	CC BY 4.0 info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Biophysics Evolutionary Biology Ecology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified secreting cell compartments na &# 239 inform vaccine design focusing ab responses arms &# 8221 11 amino acids multiple independent insertions two founder viruses single antibody position potent bnab lineage founder viruses including insertions virus separated unusual features subtype c predominantly atypical potential enhancer neutralization breadth longitudinal studies indels ). humoral system help stabilize findings suggest extensive recombination evolved independently early exposure antigen pressure
dc.title.none.fl_str_mv	PC39-1 mAb sequence alignment.
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>Alignments of HC (top) and LC (bottom) of the PC39-1 mAbs, relative to the UCA/iGL sequences, with regions indicated and colored by residue, according to the given key, showing accumulated mutations in the mAbs over time. mAb names are colored by antibody CDRH1 insertion and ordered by isolation time point.</p> <p>(TIF)</p>
eu_rights_str_mv	openAccess
id	Manara_79d9fb8744e02458b44b9a7cb1567398
identifier_str_mv	10.1371/journal.ppat.1011416.s002
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/23601589
publishDate	2023
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY 4.0
spelling	PC39-1 mAb sequence alignment.Collin Joyce (16469212)Sasha Murrell (16469215)Ben Murrell (151760)Oluwarotimi Omorodion (3287124)Lorena S. Ver (16469218)Nancy Carrico (16469221)Raiza Bastidas (16469224)Rebecca Nedellec (348332)Michael Bick (16469227)Jordan Woehl (16469230)Fangzhu Zhao (12476373)Alison Burns (12476367)Shawn Barman (12476370)Michael Appel (16469233)Alejandra Ramos (386538)Lalinda Wickramasinghe (845747)Kemal Eren (6083528)Thomas Vollbrecht (492146)Davey M. Smith (12883985)Sergei L. Kosakovsky Pond (8321352)Ryan McBride (409526)Charli Worth (7326596)Facundo Batista (9104558)Devin Sok (409518)Pascal Poignard (244468)Bryan Briney (488298)Ian A. Wilson (113692)Elise Landais (845745)Dennis R. Burton (106420)BiophysicsEvolutionary BiologyEcologyImmunologyCancerInfectious DiseasesVirologyBiological Sciences not elsewhere classifiedsecreting cell compartmentsna &# 239inform vaccine designfocusing ab responsesarms &# 822111 amino acidsmultiple independent insertionstwo founder virusessingle antibody positionpotent bnab lineagefounder virusesincluding insertionsvirus separatedunusual featuressubtype cpredominantly atypicalpotential enhancerneutralization breadthlongitudinal studiesindels ).humoral systemhelp stabilizefindings suggestextensive recombinationevolved independentlyearly exposureantigen pressure<p>Alignments of HC (top) and LC (bottom) of the PC39-1 mAbs, relative to the UCA/iGL sequences, with regions indicated and colored by residue, according to the given key, showing accumulated mutations in the mAbs over time. mAb names are colored by antibody CDRH1 insertion and ordered by isolation time point.</p> <p>(TIF)</p>2023-06-29T17:44:06ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1011416.s002https://figshare.com/articles/figure/PC39-1_mAb_sequence_alignment_/23601589CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/236015892023-06-29T17:44:06Z
spellingShingle	PC39-1 mAb sequence alignment. Collin Joyce (16469212) Biophysics Evolutionary Biology Ecology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified secreting cell compartments na &# 239 inform vaccine design focusing ab responses arms &# 8221 11 amino acids multiple independent insertions two founder viruses single antibody position potent bnab lineage founder viruses including insertions virus separated unusual features subtype c predominantly atypical potential enhancer neutralization breadth longitudinal studies indels ). humoral system help stabilize findings suggest extensive recombination evolved independently early exposure antigen pressure
status_str	publishedVersion
title	PC39-1 mAb sequence alignment.
title_full	PC39-1 mAb sequence alignment.
title_fullStr	PC39-1 mAb sequence alignment.
title_full_unstemmed	PC39-1 mAb sequence alignment.
title_short	PC39-1 mAb sequence alignment.
title_sort	PC39-1 mAb sequence alignment.
topic	Biophysics Evolutionary Biology Ecology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified secreting cell compartments na &# 239 inform vaccine design focusing ab responses arms &# 8221 11 amino acids multiple independent insertions two founder viruses single antibody position potent bnab lineage founder viruses including insertions virus separated unusual features subtype c predominantly atypical potential enhancer neutralization breadth longitudinal studies indels ). humoral system help stabilize findings suggest extensive recombination evolved independently early exposure antigen pressure

PC39-1 mAb sequence alignment.

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