PC39-1 mAb sequence alignment.

PC39-1 mAb sequence alignment.

<p>Alignments of HC (top) and LC (bottom) of the PC39-1 mAbs, relative to the UCA/iGL sequences, with regions indicated and colored by residue, according to the given key, showing accumulated mutations in the mAbs over time. mAb names are colored by antibody CDRH1 insertion and ordered by isol...

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Podrobná bibliografie
Hlavní autor:	Collin Joyce (16469212) (author)
Další autoři:	Sasha Murrell (16469215) (author), Ben Murrell (151760) (author), Oluwarotimi Omorodion (3287124) (author), Lorena S. Ver (16469218) (author), Nancy Carrico (16469221) (author), Raiza Bastidas (16469224) (author), Rebecca Nedellec (348332) (author), Michael Bick (16469227) (author), Jordan Woehl (16469230) (author), Fangzhu Zhao (12476373) (author), Alison Burns (12476367) (author), Shawn Barman (12476370) (author), Michael Appel (16469233) (author), Alejandra Ramos (386538) (author), Lalinda Wickramasinghe (845747) (author), Kemal Eren (6083528) (author), Thomas Vollbrecht (492146) (author), Davey M. Smith (12883985) (author), Sergei L. Kosakovsky Pond (8321352) (author), Ryan McBride (409526) (author), Charli Worth (7326596) (author), Facundo Batista (9104558) (author), Devin Sok (409518) (author), Pascal Poignard (244468) (author), Bryan Briney (488298) (author), Ian A. Wilson (113692) (author), Elise Landais (845745) (author), Dennis R. Burton (106420) (author)
Vydáno:	2023
Témata:	Biophysics Evolutionary Biology Ecology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified secreting cell compartments na &# 239 inform vaccine design focusing ab responses arms &# 8221 11 amino acids multiple independent insertions two founder viruses single antibody position potent bnab lineage founder viruses including insertions virus separated unusual features subtype c predominantly atypical potential enhancer neutralization breadth longitudinal studies indels ). humoral system help stabilize findings suggest extensive recombination evolved independently early exposure antigen pressure
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Podobné jednotky

PC39-1 mAb NGS.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Alanine scanning mutagenesis of gp120 binding to select PC39-1 mAbs.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Development of a broadly neutralizing antibody response in donor PC39 and characteristics and phylogeny of PC39-1 bnAbs.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

PC39 virus evolution and escape from bnAb lineage.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

PC39-1 UCA and pre-insertion Ab binding to autologous gp120s.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

PC39-1 bnAb isolation and 37-virus panel neutralization results.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

PC39 virus sequencing.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

PC39 antibody next generation sequencing.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

X-ray data collection and refinement statistics for PC39-55C and PC39-1 UCA Fab structures.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

X-ray data collection and refinement statistics for PC39-50E and PC39-50L Fab structures.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

X-ray data collection and refinement statistics for PC39-17A and PC39-50I Fab structures.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

X-ray structures of PC39-1 Fabs.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

X-ray data collection and refinement statistics for PC39-23D Fab structure.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Number of peripheral memory B cells profiled by single-cell RNA-sequencing with corresponding density plot showing B cell abundance in donor PC39 at each time-point.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Antibody insertion statistics compiled from a large-scale repertoire sequencing study [90] and previously studied Protocol C donors [21, 23, 27].
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Comparison of V3-glycan targeting antibody structures.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Mutational scanning of autologous virus.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Identification of Memory B Cell Phenotypes from Gene Expression Data.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

109-virus panel neutralization results.
Autor: Collin Joyce (16469212)
Vydáno: (2023)

Signature sites identified between MSM and HSX Founder viruses in Env using a phylogenetic corrected method.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Previously described signature sites enriched in HSX Founder viruses.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Multiplicity of HIV-1 infection in HSX, MSM and IDU subjects.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Mapping of signature sites on the three-dimensional structure of gp120 shows clustering around the CD4-binding site.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Selection bias intensified for HSX founder viruses compared to MSM founder viruses.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Complexity of acute HIV-1 infection revealed using deep sequencing data and the APHD approach.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Subject 654207 exhibits high <i>env</i> diversity by both 454 and SGA/S reflective of multiple founder viruses.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Subject 571373 exhibits low <i>env</i> diversity by both 454 and SGA/S reflective of a single founder virus.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Mean average pairwise Hamming distance (APHD) of HIV-1 Env SGA/S sequences distinguishes between single and multiple founder viruses.
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus
Autor: Damien C. Tully (178488)
Vydáno: (2016)

Number of polymorphic sites in broad and non-broad neutralizers.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Multiple founders boosted diversification in broad neutralizers.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Higher diversity in infections with multiple founders in early infection.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Association between infections with multiple founders and neutralization breadth.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

No evidence of heritability of neutralization breadth.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Relationship between the number of polymorphic sites and neutralization breadth in the RV217 cohort.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Minority variants at polymorphic sites in the RV217 cohort.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Higher numbers of polymorphic sites in broad neutralizers and in infections with multiple founders.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Neutralization breadth over time in broad neutralizers with single or multiple founder infections in the RV217 cohort.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Sensitivity and specificity of heritability estimates on simulated data.
Autor: Eric Lewitus (663146)
Vydáno: (2022)

Phylogenetic heritability for phylogenies constructed from RV217 and RV144 consensus sequences.
Autor: Eric Lewitus (663146)
Vydáno: (2022)