Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2<sup>+</sup> Breast Cancer

Ionizable lipid nanoparticles (LNPs) have enabled significant advances in oligonucleotide (ON) therapeutics, resulting in the approval of the short interfering RNA (siRNA)-based formulation Onpattro. However, achieving cell-specific delivery remains challenging. We have developed palmitate-containin...

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Autor Principal:	Pedro Medina (454632) (author)
Outros autores:	Modesto Orozco (10295) (author), Montserrat Terrazas (2195023) (author)
Publicado:	2025
Subjects:	Biophysics Biochemistry Medicine Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Computational Biology Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified sup >+</ sup short interfering rna palmitic acid inclusion novel lnp formulation enabled significant advances containing lipid nanoparticles tumor cells compared breast cancer cells demonstrating strong potential dually decorated palmitate based targeted therapies sensitive cells targeted delivery potential use combinatorial therapies targeting peptide sirna combination results support promoting genes diverse tumors developed palmitate combination treatments achieving cell
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Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2<sup>+</sup> Breast Cancer

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