Phosphorylation of GntR reduced bacterial virulence.

(A) BALB/c mice were challenged by intraperitoneal injection with WT SS2, ΔgntR, GntR-S41A, and GntR-S41E at a dose of 5×108 CFUs/mice (n = 5 mice/group), and the survival time was monitored. (B-F) Bacterial loads in the blood (B), lung (C), liver (...

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Main Author:	Kai Niu (818117) (author)
Other Authors:	Yu Meng (152553) (author), Mingxing Liu (141843) (author), Zhe Ma (167751) (author), Huixing Lin (4033031) (author), Hong Zhou (29614) (author), Hongjie Fan (167764) (author)
Published:	2023
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified sup >+</ sup potential substrate protein div >< p reduced bacterial load complementing transcript levels resist oxidative stress oxidative stress resistance streptococcus suis </ s41e mutant compared s41e cannot bind significantly reduced lethality infected mice compared phosphomimetic protein gntr phosphorylation experiments showed stk phosphorylated gntr gntr transcription factor oxidative stress significantly reduced transcription levels phosphomimetic strain experiments demonstrated gntr reduces gntr phosphorylation vivo </ vitro </ s41e strain study confirmed still unclear serotype 2 regulation mechanisms likely accumulated chromatin immunoprecipitation
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Phosphorylation of GntR reduced bacterial virulence.

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