BL1249 increases Po but not γ in high ionic strength.

a) Single channel traces of TREK ΔM3 in 1M intracellular KCl at -104 mV (-50 mV driving force). a’ Enlarged view of individual openings in each trace (75 ms). b) All point amplitude histogram of the recordings shown (partially) in panel a, total length...

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Bibliographic Details
Main Author:	Linus J. Conrad (11534658) (author)
Other Authors:	Peter Proks (5233553) (author), Stephen J. Tucker (2002873) (author)
Published:	2021
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Neuroscience Physiology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified sup >+</ sup small molecule agonists negatively charged activators lack canonical vsds dependent behavior mediated polymodal k2p k dependent gating behaviors channel open probability div >< p gating process mediated high internal k voltage sensing process single channel conductance internal k channel conductance channel gating channel currents trek2 responds still able selectivity filter permeating ion membrane voltage inner cavity high ionic growing number directly probed common thread classical voltage binding within also suggest activatory effect
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BL1249 increases <i>Po</i> but not <i>γ</i> in high ionic strength.

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