AKAP/AC nanodomain formation can be explained by Turing patterns.
<p>(A) The phase diagram of Turing pattern for parameters <i>v</i><sub><i>r</i></sub> and <i>v</i><sub><i>s</i></sub> (upper left panel), <i>β</i> and <i>b</i> (upper middle panel), and <i>m&l...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2024
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| الملخص: | <p>(A) The phase diagram of Turing pattern for parameters <i>v</i><sub><i>r</i></sub> and <i>v</i><sub><i>s</i></sub> (upper left panel), <i>β</i> and <i>b</i> (upper middle panel), and <i>m</i><sub>2</sub> and <i>μ</i> (upper right panel). Three patterns occur in the parameter space: the first is that the AC (denoted by <i>r</i>) and AKAP (denoted by <i>s</i>) are uniformly distributed; the second is the Turing pattern where the AKAP and AC are co-localized, which is denoted as Turing pattern 1; the third is also a Turing pattern but the AC level is high outside the AKAP cluster, which is referred to as Turing pattern 2. Typical distributions of AC and AKAP for these three types of pattern are shown in lower panels. The marker over the plot indicates the value of <i>D</i><sub><i>r</i></sub>, <i>D</i><sub><i>s</i></sub>, <i>β</i>, <i>b</i>, <i>m</i><sub>2</sub> and <i>μ</i>. (B) The dynamics of Ca<sup>2+</sup> and cAMP on (i) or outside AKAP/AC nanodomains (ii) when initial conditions of AC and AKAP are re-scaled from the lower middle panel in (A). When the maximal concentration of AC is same as that in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012564#pcbi.1012564.g006" target="_blank">Fig 6</a>, the cAMP oscillates in phase with Ca<sup>2+</sup> on and outside AKAP/AC nanodomains (upper right panel); when the AC level is one eighth of that in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012564#pcbi.1012564.g006" target="_blank">Fig 6</a>, the cAMP oscillates in phase with Ca<sup>2+</sup> on AKAP/AC nanodomains but out of phase with Ca<sup>2+</sup> outside AKAP/AC nanodomains (lower right panel). (C) The in-phase and inversely out-of-phase oscillations in (B). (D) The time delay in (B) as a function of the distance <i>x</i> to the center of AKAP/AC nanodomains.</p> |
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