Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates

Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates

The first asymmetric total synthesis of the bisbenzylisoquinoline alkaloids berbamine (<b>1a</b>) and oxyacanthine (<b>1b</b>) has been accomplished by employing Noyori asymmetric hydrogenation for chirality installation and leveraging copper-mediated Ullmann coupling for mac...

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Autor principal: Li Xiang (586649) (author)
Otros Autores: Jishan Qin (20535872) (author), Temur Kushatov (22687969) (author), Firdavsi Tursunov (22687972) (author), Ozod Farmonov (22687975) (author), Xiangrui Jiang (1601968) (author), Feipu Yang (2937366) (author), Jingshan Shen (1601962) (author), Khurshed Bozorov (5517845) (author), Haji Akber Aisa (7312430) (author)
Publicado: 2025
Materias:
Biochemistry
Microbiology
Physiology
Biotechnology
Ecology
Immunology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
synthesis unequivocally confirmed
stimulated raw 264
promising lead candidate
mediated ullmann coupling
asymmetric total synthesis
inflammatory activities revealed
15a </ b
inflammatory activity coupled
displayed potent anti
inflammatory cytokines il
oxyacanthine (< b
inflammatory activity
inflammatory agents
sample misidentification
related intermediates
previous work
novel anti
minimal cytotoxicity
macrocycle formation
leveraging copper
chirality installation
7 macrophages
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