Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates

The first asymmetric total synthesis of the bisbenzylisoquinoline alkaloids berbamine (<b>1a</b>) and oxyacanthine (<b>1b</b>) has been accomplished by employing Noyori asymmetric hydrogenation for chirality installation and leveraging copper-mediated Ullmann coupling for mac...

Celý popis

Uloženo v:

Podrobná bibliografie
Hlavní autor:	Li Xiang (586649) (author)
Další autoři:	Jishan Qin (20535872) (author), Temur Kushatov (22687969) (author), Firdavsi Tursunov (22687972) (author), Ozod Farmonov (22687975) (author), Xiangrui Jiang (1601968) (author), Feipu Yang (2937366) (author), Jingshan Shen (1601962) (author), Khurshed Bozorov (5517845) (author), Haji Akber Aisa (7312430) (author)
Vydáno:	2025
Témata:	Biochemistry Microbiology Physiology Biotechnology Ecology Immunology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified synthesis unequivocally confirmed stimulated raw 264 promising lead candidate mediated ullmann coupling asymmetric total synthesis inflammatory activities revealed 15a </ b inflammatory activity coupled displayed potent anti inflammatory cytokines il oxyacanthine (< b inflammatory activity inflammatory agents sample misidentification related intermediates previous work novel anti minimal cytotoxicity macrocycle formation leveraging copper chirality installation 7 macrophages
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates

Podobné jednotky