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<div><p>Persistence of the HIV-1 reservoir is the major barrier to a cure. Little is known about the dynamics of the proviral integration site landscape and inducibility of the viral reservoir in early-treated individuals. Here, we perform a longitudinal analysis of the viral reservoir i...

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Main Author:	Tine Struyve (22683295) (author)
Other Authors:	Marion Pardons (6407921) (author), Jozefien De Clercq (17737815) (author), Liesbet Termote (22683298) (author), Laurens Lambrechts (10532207) (author), Ytse Noppe (22683301) (author), Mathias Lichterfeld (57148) (author), Sofie Rutsaert (10667718) (author), Linos Vandekerckhove (105574) (author)
Published:	2025
Subjects:	Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected
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