Data Sheet 1_Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity.pdf
Introduction<p>Increased CYP3A-mediated drug clearance during pregnancy can lead to subtherapeutic dosing of CYP3A substrates. Pregnancy-related hormones (PRHs) increase CYP3A4 expression and activity in cultured human hepatocytes. However, the factors in maternal circulation that regulate pre...
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