Table 1_Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia.xlsx

Table 1_Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia.xlsx

Introduction:<p>Tooth agenesis (TA) is a common craniofacial malformation in humans, characterized by the absence of one or more permanent teeth. Recent studies have identified the low-density lipoprotein receptor-related protein 6 (LRP6) gene as an autosomal dominant contributor to TA. Herein...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Yunyun Yuan (1448947) (author)
مؤلفون آخرون:	Ya Zhao (807581) (author), Lingqiang Meng (2901497) (author), Shuyun Zheng (611010) (author), Hui Li (32376) (author), Jiabao Ren (14847457) (author), Beibei Li (280092) (author), Chenyun Dou (21477611) (author), Yan Hou (207152) (author), Wenjing Chen (383602) (author), Jing Zhang (23775) (author), Yulin Ding (10980944) (author), Wenjing Shen (494177) (author)
منشور في:	2025
الموضوعات:	Genetics tooth agenesis non-syndromic oligodontia LRP6 β-catenin genotype-phenotype
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة

Table 2_Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia.xlsx
حسب: Yunyun Yuan (1448947)
منشور في: (2025)

Table 3_Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia.xlsx
حسب: Yunyun Yuan (1448947)
منشور في: (2025)

Image 1_Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia.pdf
حسب: Yunyun Yuan (1448947)
منشور في: (2025)

Sanger sequencing of LRP6 knockout using CRISPR-Cas9
حسب: Hengxing (20640818)
منشور في: (2025)

Data Sheet 1_Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancer.docx
حسب: Yuan Liu (88411)
منشور في: (2025)

Analysis of vertical and sagittal dimensions parameters.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Analysis of transverse dimension parameters.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Multivariate regression model.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Flow chart.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Frontal cephalometry.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Cephalometric profile.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Raw demographic and radiographic data from medical records.
حسب: Damien Brézulier (17711996)
منشور في: (2024)

Image 1_Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway.tif
حسب: Yawei Tian (5607704)
منشور في: (2025)

Image 2_Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway.tif
حسب: Yawei Tian (5607704)
منشور في: (2025)

Data Sheet 1_Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway.docx
حسب: Yawei Tian (5607704)
منشور في: (2025)

Data Sheet 1_Effect of chronic alcohol feeding using the Lieber-DeCarli diet on Alzheimer’s disease pathology in Tg2576 mice.docx
حسب: Devaraj V. Chandrashekar (13797412)
منشور في: (2025)

CTNNB1 pathogenic variants analysed in the study.
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Relative expression levels of the β-catenin variants analysed in this study.
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Schematic depiction of the <i>CTNNB1</i> variants analysed in this study.
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

(A) Expression of β-catenin variants analysed in this study. COS-7 cells were transfected with pRK5 mammalian expression plasmid encoding the indicated β-catenin variants (EV, empty vector; WT, wild type), and cell lysates were analysed by immunoblot with anti-β-catenin N-terminal (N-term) or C-terminal (C-term) antibodies, as indicated. Immunoblots with anti-GAPDH are shown as controls. (B) Schematic representation of the β-catenin proteoforms generated by the β-catenin variants analysed in this study. Lines indicate the relative length of the different proteoforms. (C) Transcriptional activity of β-catenin variants. COS-7 cells were transfected with plasmids encoding the indicated β-catenin variants (EV, empty vector; WT, wild type), and processed for TCF/LEF-driven luciferase activity. Luminescence is shown in arbitrary units (AU), from at least two independent experiments (SEAP, secreted alkaline phosphatase).
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

<i>Supporting data for </i><i>“</i>Functional characterization of low-density lipoprotein receptor-related protein 1B (LRP1B) and Mitotic arrest deficient 2 like 2 (MAD2L2) in esophageal squamous cell carcinoma (ESCC<b>)</b><i>”</i>
حسب: Kaiyan Xu (9391655)
منشور في: (2024)

Tissue-specific CRISPR/Cas9-mediated mutagenesis of <i>Agrin</i> and <i>Lrp4.</i>
حسب: Md. Faruk Hossain (16920619)
منشور في: (2025)

Reconstitution of β-catenin function by proteasome inhibition. (A) COS-7 cells were transfected with plasmids encoding the β-catenin variants (WT, wild type) and kept untreated (-) or incubated (+) in the presence of MG-132 (10 μM) or cycloheximide (CHX, 800 μg/ml) for 6 h. The left panel shows representative immunoblots using anti-β-catenin N-terminal or anti-GAPDH antibodies. The right panel shows the relative quantification of the bands from each variant, from at least two independent experiments. **, p = 0.0003; ***, p < 0.0001. (B) Transcriptional activity of β-catenin variants. COS-7 cells were transfected with plasmids encoding the indicated β-catenin variants (EV, empty vector; WT, wild type) and kept untreated (Control) or incubated in the presence of MG-132 (10 μM) for 6 h, as indicated. Cells were processed for TCF/LEF-driven luciferase activity, and luminescence is shown in arbitrary units (AU), fr
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Reconstitution of β-catenin function by translational readthrough. (A) COS-7 cells were transfected with plasmids encoding the β-catenin variants (EV, empty vector; WT, wild type) and kept untreated (-) or incubated (+) in the presence of G418 (200 μg/ml) for 24 h. A representative immunoblot is shown using anti-β-catenin N-terminal or anti-GAPDH antibodies. (B) COS-7 cells were transfected with plasmids encoding the R474* β-catenin variant (EV, empty vector; WT, wild type) and kept untreated (-) or incubated (+) in the presence of G418 (200 μg/ml) and Y-320 (1 μM) for 24 h, as indicated. The top panel shows a representative immunoblot using anti-β-catenin N-terminal or anti-GAPDH antibodies. The bottom panel shows the relative quantification of the β-catenin full-length bands from each variant, from at least two independent experiments. *, p = 0.0133. (C) Transcriptional activity of β-catenin variants. COS-7 cells
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Image 3_Case Report: Diagnostic overlap of OHVIRA syndrome and Gartner duct cyst: challenges in imaging and management.tif
حسب: Junfeng Zhao (2745940)
منشور في: (2025)

Image 2_Case Report: Diagnostic overlap of OHVIRA syndrome and Gartner duct cyst: challenges in imaging and management.tif
حسب: Junfeng Zhao (2745940)
منشور في: (2025)

Image 1_Case Report: Diagnostic overlap of OHVIRA syndrome and Gartner duct cyst: challenges in imaging and management.tif
حسب: Junfeng Zhao (2745940)
منشور في: (2025)

Table 1_Case Report: Diagnostic overlap of OHVIRA syndrome and Gartner duct cyst: challenges in imaging and management.pdf
حسب: Junfeng Zhao (2745940)
منشور في: (2025)

Image 5_Case Report: Diagnostic overlap of OHVIRA syndrome and Gartner duct cyst: challenges in imaging and management.tif
حسب: Junfeng Zhao (2745940)
منشور في: (2025)

Image 4_Case Report: Diagnostic overlap of OHVIRA syndrome and Gartner duct cyst: challenges in imaging and management.tif
حسب: Junfeng Zhao (2745940)
منشور في: (2025)

Stability of β-catenin variants. (A) COS-7 cells were transfected with plasmids encoding the β-catenin variants (EV, empty vector; WT, wild type) and kept untreated (-) or incubated (+) in the presence of cycloheximide (CHX, 800 μg/ml) for 6 h to monitor protein degradation. The top panel shows a representative immunoblot using sequentially anti-β-catenin N-terminal and C-terminal antibodies. The bottom panel shows the relative quantification of the representative bands from each variant. Bars represent the relative expression after CHX treatment, with regard to the expression under the untreated conditions ± SD, from at least two independent experiments. (B) COS-7 cells were processed as in (A) and kept untreated (0) or incubated in the presence of cycloheximide (CHX, 800 μg/ml) for 2h or 6 h, as indicated. Immunoblots were performed using anti-β-catenin N-terminal or anti-GAPDH antibodies, as indicated. In the left panel,
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Summary model diagram of a conserved <i>Nova-Agrin-Lrp4</i> pathway for AChR clustering in <i>Ciona.</i>
حسب: Md. Faruk Hossain (16920619)
منشور في: (2025)

Differences between the High stability (H) and Low stability (L) groups of patients in cognitive performance.
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

(A) Expression of N-terminal and C-terminal truncated β-catenin proteoforms.
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Data that underlies this paper.
حسب: Caroline E. Nunes-Xavier (3607922)
منشور في: (2025)

Images of Western blots in Figure 2b-c.
حسب: Alaullah Sheikh (8722854)
منشور في: (2025)

Video 1_Laparoscopy-assisted uterovaginal anastomosis in a patient with atypical cervicovaginal malformation: a case report.mp4
حسب: Antoine Naem (20886608)
منشور في: (2025)

Table 1_Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML.docx
حسب: Yingying Zhou (417062)
منشور في: (2025)

Data Sheet 1_Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML.docx
حسب: Yingying Zhou (417062)
منشور في: (2025)

Image 3_Diagnosis and surgical treatment of obstructed hemivagina and ipsilateral renal anomaly in a dog: a case report.jpeg
حسب: Younwoo Choo (20468081)
منشور في: (2024)

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