Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance

<p>Supplemental Figure S2 shows UMAP plots, entropy analysis, quantification of barcode abundance, cell sensitivity to drug, and average gene signature set expression in sensitive vs tolerant clones.</p>

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1. autor: Jennifer L. Cotton (17315204) (author)
Kolejni autorzy: Javier Estrada Diez (17315207) (author), Vivek Sagar (17315210) (author), Julie Chen (17315213) (author), Michelle Piquet (15460169) (author), John Alford (17315216) (author), Youngchul Song (17315219) (author), Xiaoyan Li (17315222) (author), Markus Riester (17315225) (author), Matthew T. DiMare (17315228) (author), Katja Schumacher (17315231) (author), Gaylor Boulay (17315234) (author), Kathleen Sprouffske (15099146) (author), Lin Fan (17315237) (author), Tyler Burks (17315240) (author), Leandra Mansur (17315243) (author), Joel Wagner (17315246) (author), Hyo-eun C. Bhang (17315249) (author), Oleg Iartchouk (17315252) (author), John Reece-Hoyes (17315255) (author), Erick J. Morris (17315258) (author), Peter S. Hammerman (17315261) (author), David A. Ruddy (15460166) (author), Joshua M. Korn (17315264) (author), Jeffrey A. Engelman (17315267) (author), Matthew J. Niederst (17315270) (author)
Wydane: 2025
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author Jennifer L. Cotton (17315204)
author2 Javier Estrada Diez (17315207)
Vivek Sagar (17315210)
Julie Chen (17315213)
Michelle Piquet (15460169)
John Alford (17315216)
Youngchul Song (17315219)
Xiaoyan Li (17315222)
Markus Riester (17315225)
Matthew T. DiMare (17315228)
Katja Schumacher (17315231)
Gaylor Boulay (17315234)
Kathleen Sprouffske (15099146)
Lin Fan (17315237)
Tyler Burks (17315240)
Leandra Mansur (17315243)
Joel Wagner (17315246)
Hyo-eun C. Bhang (17315249)
Oleg Iartchouk (17315252)
John Reece-Hoyes (17315255)
Erick J. Morris (17315258)
Peter S. Hammerman (17315261)
David A. Ruddy (15460166)
Joshua M. Korn (17315264)
Jeffrey A. Engelman (17315267)
Matthew J. Niederst (17315270)
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author_facet Jennifer L. Cotton (17315204)
Javier Estrada Diez (17315207)
Vivek Sagar (17315210)
Julie Chen (17315213)
Michelle Piquet (15460169)
John Alford (17315216)
Youngchul Song (17315219)
Xiaoyan Li (17315222)
Markus Riester (17315225)
Matthew T. DiMare (17315228)
Katja Schumacher (17315231)
Gaylor Boulay (17315234)
Kathleen Sprouffske (15099146)
Lin Fan (17315237)
Tyler Burks (17315240)
Leandra Mansur (17315243)
Joel Wagner (17315246)
Hyo-eun C. Bhang (17315249)
Oleg Iartchouk (17315252)
John Reece-Hoyes (17315255)
Erick J. Morris (17315258)
Peter S. Hammerman (17315261)
David A. Ruddy (15460166)
Joshua M. Korn (17315264)
Jeffrey A. Engelman (17315267)
Matthew J. Niederst (17315270)
author_role author
dc.creator.none.fl_str_mv Jennifer L. Cotton (17315204)
Javier Estrada Diez (17315207)
Vivek Sagar (17315210)
Julie Chen (17315213)
Michelle Piquet (15460169)
John Alford (17315216)
Youngchul Song (17315219)
Xiaoyan Li (17315222)
Markus Riester (17315225)
Matthew T. DiMare (17315228)
Katja Schumacher (17315231)
Gaylor Boulay (17315234)
Kathleen Sprouffske (15099146)
Lin Fan (17315237)
Tyler Burks (17315240)
Leandra Mansur (17315243)
Joel Wagner (17315246)
Hyo-eun C. Bhang (17315249)
Oleg Iartchouk (17315252)
John Reece-Hoyes (17315255)
Erick J. Morris (17315258)
Peter S. Hammerman (17315261)
David A. Ruddy (15460166)
Joshua M. Korn (17315264)
Jeffrey A. Engelman (17315267)
Matthew J. Niederst (17315270)
dc.date.none.fl_str_mv 2025-11-24T23:22:09Z
dc.identifier.none.fl_str_mv 10.1158/0008-5472.30701039
dc.relation.none.fl_str_mv https://figshare.com/articles/figure/Supplemental_Figure_S2_from_Expressed_Barcoding_Enables_High-Resolution_Tracking_of_the_Evolution_of_Drug_Tolerance/30701039
dc.rights.none.fl_str_mv CC BY
info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv Cancer
Tumor Biology
Therapeutic Research and Development
Methods and Technology
Drug Resistance
Lung Cancer
Single Cell Technologies
Tumor Heterogeneity
dc.title.none.fl_str_mv Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
dc.type.none.fl_str_mv Image
Figure
info:eu-repo/semantics/publishedVersion
image
description <p>Supplemental Figure S2 shows UMAP plots, entropy analysis, quantification of barcode abundance, cell sensitivity to drug, and average gene signature set expression in sensitive vs tolerant clones.</p>
eu_rights_str_mv openAccess
id Manara_7f021c5a6962047e583d7b6ccb55aa41
identifier_str_mv 10.1158/0008-5472.30701039
network_acronym_str Manara
network_name_str ManaraRepo
oai_identifier_str oai:figshare.com:article/30701039
publishDate 2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
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rights_invalid_str_mv CC BY
spelling Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug ToleranceJennifer L. Cotton (17315204)Javier Estrada Diez (17315207)Vivek Sagar (17315210)Julie Chen (17315213)Michelle Piquet (15460169)John Alford (17315216)Youngchul Song (17315219)Xiaoyan Li (17315222)Markus Riester (17315225)Matthew T. DiMare (17315228)Katja Schumacher (17315231)Gaylor Boulay (17315234)Kathleen Sprouffske (15099146)Lin Fan (17315237)Tyler Burks (17315240)Leandra Mansur (17315243)Joel Wagner (17315246)Hyo-eun C. Bhang (17315249)Oleg Iartchouk (17315252)John Reece-Hoyes (17315255)Erick J. Morris (17315258)Peter S. Hammerman (17315261)David A. Ruddy (15460166)Joshua M. Korn (17315264)Jeffrey A. Engelman (17315267)Matthew J. Niederst (17315270)CancerTumor BiologyTherapeutic Research and DevelopmentMethods and TechnologyDrug ResistanceLung CancerSingle Cell TechnologiesTumor Heterogeneity<p>Supplemental Figure S2 shows UMAP plots, entropy analysis, quantification of barcode abundance, cell sensitivity to drug, and average gene signature set expression in sensitive vs tolerant clones.</p>2025-11-24T23:22:09ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30701039https://figshare.com/articles/figure/Supplemental_Figure_S2_from_Expressed_Barcoding_Enables_High-Resolution_Tracking_of_the_Evolution_of_Drug_Tolerance/30701039CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307010392025-11-24T23:22:09Z
spellingShingle Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
Jennifer L. Cotton (17315204)
Cancer
Tumor Biology
Therapeutic Research and Development
Methods and Technology
Drug Resistance
Lung Cancer
Single Cell Technologies
Tumor Heterogeneity
status_str publishedVersion
title Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
title_full Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
title_fullStr Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
title_full_unstemmed Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
title_short Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
title_sort Supplemental Figure S2 from Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
topic Cancer
Tumor Biology
Therapeutic Research and Development
Methods and Technology
Drug Resistance
Lung Cancer
Single Cell Technologies
Tumor Heterogeneity