N. brasiliensis infection is comparable between BALB/c and IL-4Rα−/lox mice.

Five mice per group were infected with 750 N. brasiliensis L3 larvae. Faeces were collected from day 5 to 10 post infection (PI) and egg production was calculated using the modified McMaster technique (A). At days 7 and 10 PI the worm burden in the small intestine was ass...

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المؤلف الرئيسي:	Saskia Schmidt (109610) (author)
مؤلفون آخرون:	J. Claire Hoving (7407029) (author), William G. C. Horsnell (12696689) (author), Helen Mearns (109612) (author), Antony J. Cutler (9024605) (author), Tiroyaone Masego H. Bogale (22681164) (author), Frank Brombacher (52142) (author)
منشور في:	2025
الموضوعات:	Microbiology Cell Biology Genetics Molecular Biology Immunology Developmental Biology Cancer Science Policy Computational Biology Biological Sciences not elsewhere classified parasite induced effects important physiological manifestation div >< p alternative macrophage activation achieved using pan 4r &# 945 resulting increased il sup >+</ sup intestinal inflammation associated goblet cell hyperplasia cre </ sup 4 receptor alpha strikingly reduced il reduced intestinal il responsive control mice deficient mice led nippostrongylus brasiliensis </ 2 response results nippostrongylus </ brasiliensis </ reduced il deficient mice control mice results demonstrate specific il impaired il global il 13 response mice showed local infiltration immune responses ige responses helper cell contribute significantly cell responses 4 production
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الوصف
الملخص:	<p>Five mice per group were infected with 750 <i>N. brasiliensis</i> L3 larvae. Faeces were collected from day 5 to 10 post infection (PI) and egg production was calculated using the modified McMaster technique (A). At days 7 and 10 PI the worm burden in the small intestine was assessed (B). Intestinal goblet cell hyperplasia was assessed by determining the total number of PAS-positive goblet cells per 5 villi in histological sections of the small intestine at day 7 and 10 PI (C). Total IgE production in the serum was measured by ELISA at day 7 and 10 PI (D). Comparison of the response of infected BALB/c and IL-4Rα<sup>−/lox</sup> mice to acetylcholine is also shown for day 7 p.i. The data represents one (A-D) and two (E) independent experiment with n = 5 per group and mean values + SEM. ND, not detected. Unpaired two-tailed Student t test, ns = not significant.</p> <p>(TIF)</p>

<i>N. brasiliensis</i> infection is comparable between BALB/c and IL-4Rα<sup>−/lox</sup> mice.

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