The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS.
<p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>...
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2025
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| Sumari: | <p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>(c)</i>: Distal LTP observed when inhibition is blocked. <i>(d)</i>: Schematic of rMS simulation with electric field vector for panels e and f. <i>(e)</i>: LTP in both distal and proximal synapses when rMS is used. Unlike local electrical TBS, rMS TBS is able to induce large LTP when inhibition is present. <i>(f)</i>: LTP in both distal and proximal synapses when rMS is simulated and inhibition is blocked.</p> |
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