The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS.

The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS.

<p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>...

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Auteur principal: Nicholas Hananeia (22683665) (author)
Autres auteurs: Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Publié: 2025
Sujets:
Medicine
Cell Biology
Neuroscience
Physiology
Space Science
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
results :</ b
previous experimental studies
objective :</ b
methods :</ b
like cellular effects
conclusion :</ b
background :</ b
strongly distance dependent
scale modeling tools
repetitive magnetic stimulation
biophysical neuronal models
1 hz protocols
successfully modelled plasticity
induced synaptic plasticity
dependent plasticity model
plasticity model
dependent spatio
scale modelling
burst stimulation
5 hz
plasticity amplitude
distal plasticity
term potentiation
term changes
temporal resolution
temporal changes
rms ).
previously established
parameter screening
neurons stimulated
neuronal dendrites
modelling framework
mechanisms behind
low sensitivity
high spatio
fully understood
detailed prediction
dendritic spikes
comprehensive module
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Description
Résumé:<p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>(c)</i>: Distal LTP observed when inhibition is blocked. <i>(d)</i>: Schematic of rMS simulation with electric field vector for panels e and f. <i>(e)</i>: LTP in both distal and proximal synapses when rMS is used. Unlike local electrical TBS, rMS TBS is able to induce large LTP when inhibition is present. <i>(f)</i>: LTP in both distal and proximal synapses when rMS is simulated and inhibition is blocked.</p>

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