The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS.
<p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>...
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| Үндсэн зохиолч: | |
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| Бусад зохиолчид: | , , , , , |
| Хэвлэсэн: |
2025
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| Нөхцлүүд: | |
| Шошгууд: |
Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1849927625982607360 |
|---|---|
| author | Nicholas Hananeia (22683665) |
| author2 | Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author2_role | author author author author author author |
| author_facet | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| dc.date.none.fl_str_mv | 2025-11-25T18:42:08Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1012295.g006 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/The_synaptic_plasticity_model_reproduces_distal_LTP_for_local_electric_TBS_and_predicts_proximal_and_distal_LTP_for_rMS_TBS_/30715028 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| dc.title.none.fl_str_mv | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>(c)</i>: Distal LTP observed when inhibition is blocked. <i>(d)</i>: Schematic of rMS simulation with electric field vector for panels e and f. <i>(e)</i>: LTP in both distal and proximal synapses when rMS is used. Unlike local electrical TBS, rMS TBS is able to induce large LTP when inhibition is present. <i>(f)</i>: LTP in both distal and proximal synapses when rMS is simulated and inhibition is blocked.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_8255a1f9697f456772dad4a647e48c27 |
| identifier_str_mv | 10.1371/journal.pcbi.1012295.g006 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30715028 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS.Nicholas Hananeia (22683665)Christian Ebner (1276467)Christos Galanis (15210328)Hermann Cuntz (32618)Alexander Opitz (295799)Andreas Vlachos (47497)Peter Jedlicka (179938)MedicineCell BiologyNeurosciencePhysiologySpace ScienceBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedresults :</ bprevious experimental studiesobjective :</ bmethods :</ blike cellular effectsconclusion :</ bbackground :</ bstrongly distance dependentscale modeling toolsrepetitive magnetic stimulationbiophysical neuronal models1 hz protocolssuccessfully modelled plasticityinduced synaptic plasticitydependent plasticity modelplasticity modeldependent spatioscale modellingburst stimulation5 hzplasticity amplitudedistal plasticityterm potentiationterm changestemporal resolutiontemporal changesrms ).previously establishedparameter screeningneurons stimulatedneuronal dendritesmodelling frameworkmechanisms behindlow sensitivityhigh spatiofully understooddetailed predictiondendritic spikescomprehensive module<p>Induction of LTP by local electrical TBS to the perforant path. <i>(a)</i>: Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). <i>(b)</i>: Negligible plasticity observed when inhibition is present. <i>(c)</i>: Distal LTP observed when inhibition is blocked. <i>(d)</i>: Schematic of rMS simulation with electric field vector for panels e and f. <i>(e)</i>: LTP in both distal and proximal synapses when rMS is used. Unlike local electrical TBS, rMS TBS is able to induce large LTP when inhibition is present. <i>(f)</i>: LTP in both distal and proximal synapses when rMS is simulated and inhibition is blocked.</p>2025-11-25T18:42:08ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1012295.g006https://figshare.com/articles/figure/The_synaptic_plasticity_model_reproduces_distal_LTP_for_local_electric_TBS_and_predicts_proximal_and_distal_LTP_for_rMS_TBS_/30715028CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307150282025-11-25T18:42:08Z |
| spellingShingle | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. Nicholas Hananeia (22683665) Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| status_str | publishedVersion |
| title | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| title_full | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| title_fullStr | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| title_full_unstemmed | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| title_short | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| title_sort | The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. |
| topic | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |