Linkage disequilibrium at SNP markers:

Shown are estimates of pairwise LD for six SNP marker loci associated with SP drug-resistance, i.e., three codons (51, 59, 108) at Pfdhfr and three codons (436, 437, 613) at Pfdhps. Panels (A, B) show values, whereas (C, D) show ALD values. Furthermore,...

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Bibliographic Details
Main Author:	Henri Christian Junior Tsoungui Obama (10432244) (author)
Other Authors:	Kristan Alexander Schneider (5076317) (author)
Published:	2025
Subjects:	Medicine Genetics Neuroscience Biotechnology Cancer Infectious Diseases Computational Biology Mathematical Sciences not elsewhere classified thereby limiting uncertainty systematic numerical simulations previously published dataset per se </ maximum likelihood using cameroon concerning sulfadoxine becoming increasingly important xlink "> molecular reasonable sample size disease control measures similar transmission pattern multiple distinct variants diseases like malaria numerically stable method infection &# 8211 sp drug pressure allelic molecular markers molecular disease surveillance malaria disease surveillance em )- algorithm deriving ld maps molecular markers allelic markers disease transmission sample properties variants associated transmission intensities pathogenic variants neutral markers temporal context statistical framework small variance several extensions second advantage readily applied proposed method particularly useful new method little bias linkage disequilibria heuristic methods haplotype frequencies genetic methods first benefit estimate ld drug resistance confounding factor best estimated avoid bias asymptotically unbiased
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Summary:	<p>Shown are estimates of pairwise LD for six SNP marker loci associated with SP drug-resistance, i.e., three codons (51, 59, 108) at <i>Pfdhfr</i> and three codons (436, 437, 613) at <i>Pfdhps</i>. Panels (A, B) show values, whereas (C, D) show ALD values. Furthermore, panels (A, C) correspond to the years 2001/2002, while panels (B, D) correspond to the years 2004/2005. The codons on <i>Pfdhfr</i> and <i>Pfdhps</i> are highlighted on the maps by horizontal black lines, with the name of the gene and codons are specified on top and below the line, respectively. The thick black lines in panels (A, B) group pairwise LD within each gene. The numbers indicate LD values.</p>

Linkage disequilibrium at SNP markers:

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