Complete list of 81 CTSZ SNPs present in Ugandan household contact study cohorts and their associations with TB severity.

TB severity was evaluated by Bandim TBScore. Summary statistics for the CTSZ variants shown are based on a meta-analysis of two independent cohorts of culture-confirmed adult TB cases (described in McHenry and colleagues, 2023 [<a href="http://www.plosbiology.org/...

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Main Author:	Rachel K. Meade (22216529) (author)
Other Authors:	Oyindamola O. Adefisayo (22216532) (author), Marco T. P. Gontijo (22216535) (author), Summer J. Harris (22216538) (author), Charlie J. Pyle (3617798) (author), Kaley M. Wilburn (12060476) (author), Alwyn M. V. Ecker (13184350) (author), Erika J. Hughes (22216541) (author), Paloma D. Garcia (22216544) (author), Joshua Ivie (22216547) (author), Michael L. McHenry (4672672) (author), Penelope H. Benchek (22216550) (author), Harriet Mayanja-Kizza (78637) (author), Jadee L. Neff (22216553) (author), Dennis C. Ko (7147757) (author), Jason E. Stout (9617361) (author), Catherine M. Stein (7359386) (author), Thomas R. Hawn (12261864) (author), David M. Tobin (8843690) (author), Clare M. Smith (8722557) (author)
Published:	2025
Subjects:	Medicine Microbiology Cell Biology Genetics Neuroscience Immunology Cancer Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified recapitulate human phenotypic outcomes vary widely mouse chromosome 2 lead candidate underlying increased bacterial burden identify significant associations placing human ctsz derived tb granulomas genetically diverse mice tb susceptibility locus tb disease severity div >< p tb susceptibility tb severity tb disease ctsz </ conserved ctsz pulmonary inflammation previously mapped ligand 1 known biomarker genotypic variation findings implicate examine patient decreased survival cxcl1 axis cxcl1 ), cathepsin z asymptomatic infection associated macrophages animal models allows identification ablation leads
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Summary:	<p>TB severity was evaluated by Bandim TBScore. Summary statistics for the <i>CTSZ</i> variants shown are based on a meta-analysis of two independent cohorts of culture-confirmed adult TB cases (described in McHenry and colleagues, 2023 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003377#pbio.3003377.ref061" target="_blank">61</a>]). Each cohort utilized a linear regression model that controlled for HIV status, sex, and one principal component. Unadjusted <i>p</i>-values are reported. Abbreviations: CHR, chromosome; BP, base pair from GRCh38 build; MAF, minor allele frequency.</p> <p>(XLSX)</p>

Complete list of 81 <i>CTSZ</i> SNPs present in Ugandan household contact study cohorts and their associations with TB severity.

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