SKN-1-mediated lysosomal enlargement is crucial for lysosomal function and longevity.

SKN-1-mediated lysosomal enlargement is crucial for lysosomal function and longevity.

<p><b>(A)</b> Ratio of <i>glp-1</i> mutants exhibiting different lysosomal morphologies in the hypodermis during aging. Chi-square and Fisher’s exact test. <i>n</i> = 33−41 animals. <b>(B</b> and <b>C)</b> Vesicular lysosomal morpholo...

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Hlavní autor:	Xinyu Wang (341591) (author)
Další autoři:	Huimin Liu (284624) (author), Xiaoman Wang (3567959) (author), Ben Zhou (197219) (author), Haiqing Tang (6645593) (author), Shanshan Pang (6645590) (author)
Vydáno:	2025
Témata:	Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Cancer Mental Health Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified active adaptive response >&# 160 ;(</ caenorhabditis elegans </ safeguards lysosomal homeostasis transcription factor skn div >< p elegans )</ lysosomal morphology lysosomal dysfunction significant changes signal transduction restricting fission potential relevance physiological significance passive consequence morphological adaptation lived germline impaired degradation functional decline function declines findings unveil deficient animals critical hubs cellular degradation also associated
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