A reproducible set of CAPs in the whole-brain rs-fMRI involve recurring mixed representations of canonical resting-state networks.
<p><b>(A)</b> Analysis overview. In each permutation, 337 subjects are randomly split into 2 equal-sized groups. Within each split, a parcel-by-time array of rs-fMRI data is temporally concatenated across subjects. Time frames are clustered based on spatial similarity using K-means...
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2024
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| Summary: | <p><b>(A)</b> Analysis overview. In each permutation, 337 subjects are randomly split into 2 equal-sized groups. Within each split, a parcel-by-time array of rs-fMRI data is temporally concatenated across subjects. Time frames are clustered based on spatial similarity using K-means clustering. The number of clusters (<i>k</i>) is estimated for each split. Each CAP is obtained as the centroid of each cluster (<b><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002808#pbio.3002808.s001" target="_blank">S1 Fig</a></b>). <b>(B)</b> Individual’s statistical preference toward a specific number of CAPs (<i>k</i>) is reproducible. In each split, an individual’s preference toward a specific number was quantified using the number of permutations that resulted in a specific solution (e.g., 4 CAPs or 5 CAPs) across 1,000 permutations. Specifically, we compute the difference (occurrence of <i>k</i> = 5)—(occurrence of <i>k</i> = 4) for each subject (<b>Methods</b>). <b>(C)</b> Spatial correlation of the 5-CAP basis set (left) and between the 4-CAP basis set and the 5-CAP basis set (right). <i>r</i> values were rounded to the nearest 2 decimal digits. <b>(D)</b> CAB-NP [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002808#pbio.3002808.ref046" target="_blank">46</a>]. <b>(E)</b> Spatial topography of 5 basis CAPs. <b>(F)</b> Spatial similarity of the 5 basis CAPs to canonical resting-state networks, predefined using the CAB-NP parcellation in (<b>D</b>). CAB-NP, Cole-Anticevic Brain Network Parcellation; CAP, co-activation pattern; rs-fMRI, resting state functional Magnetic Resonance Imaging.</p> |
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