Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses
<p dir="ltr"><i>P. aeruginosa</i> is a refractory pathogen with strong quorum sensing (QS)-regulated virulence, biofilm formation, and the ability to induce harmful inflammation in the host. To develop a strategy that minimizes the risk of resistance development, we ident...
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| अन्य लेखक: | , , , |
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2025
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| _version_ | 1849927621454856192 |
|---|---|
| author | Huiyan Li (22529084) |
| author2 | Dan-Dan Li (22529091) Huayue Li (22529130) Wen-Xin Niu (22529131) Joon-Hee Lee (22529133) |
| author2_role | author author author author |
| author_facet | Huiyan Li (22529084) Dan-Dan Li (22529091) Huayue Li (22529130) Wen-Xin Niu (22529131) Joon-Hee Lee (22529133) |
| author_role | author |
| dc.creator.none.fl_str_mv | Huiyan Li (22529084) Dan-Dan Li (22529091) Huayue Li (22529130) Wen-Xin Niu (22529131) Joon-Hee Lee (22529133) |
| dc.date.none.fl_str_mv | 2025-11-26T09:26:25Z |
| dc.identifier.none.fl_str_mv | 10.6084/m9.figshare.30490418.v5 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Marine-Derived_Bisindole_Alkaloid_R_-6_-Debromohamacanthin_B_as_a_Dual-Acting_Anti-Pathogenic_Agent_that_Targets_i_Pseudomonas_aeruginosa_i_Virulence_Biofilm_Formation_and_Host_Immune_Responses/30490418 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Bacteriology pseudomonas aeruginosa anti-pathogenic therapy Quorum sensing inhibition anti-biofilm host immune modulation |
| dc.title.none.fl_str_mv | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p dir="ltr"><i>P. aeruginosa</i> is a refractory pathogen with strong quorum sensing (QS)-regulated virulence, biofilm formation, and the ability to induce harmful inflammation in the host. To develop a strategy that minimizes the risk of resistance development, we identified the marine-derived bisindole alkaloid (R)-6'-debromohamacanthin B (RDB) as a potent anti-pathogenic compound.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_8d7dc68e5d806595bcc30539085ff5f6 |
| identifier_str_mv | 10.6084/m9.figshare.30490418.v5 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30490418 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune ResponsesHuiyan Li (22529084)Dan-Dan Li (22529091)Huayue Li (22529130)Wen-Xin Niu (22529131)Joon-Hee Lee (22529133)Bacteriologypseudomonas aeruginosaanti-pathogenic therapyQuorum sensing inhibitionanti-biofilmhost immune modulation<p dir="ltr"><i>P. aeruginosa</i> is a refractory pathogen with strong quorum sensing (QS)-regulated virulence, biofilm formation, and the ability to induce harmful inflammation in the host. To develop a strategy that minimizes the risk of resistance development, we identified the marine-derived bisindole alkaloid (R)-6'-debromohamacanthin B (RDB) as a potent anti-pathogenic compound.</p>2025-11-26T09:26:25ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.6084/m9.figshare.30490418.v5https://figshare.com/articles/dataset/Marine-Derived_Bisindole_Alkaloid_R_-6_-Debromohamacanthin_B_as_a_Dual-Acting_Anti-Pathogenic_Agent_that_Targets_i_Pseudomonas_aeruginosa_i_Virulence_Biofilm_Formation_and_Host_Immune_Responses/30490418CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304904182025-11-26T09:26:25Z |
| spellingShingle | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses Huiyan Li (22529084) Bacteriology pseudomonas aeruginosa anti-pathogenic therapy Quorum sensing inhibition anti-biofilm host immune modulation |
| status_str | publishedVersion |
| title | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| title_full | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| title_fullStr | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| title_full_unstemmed | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| title_short | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| title_sort | Marine-Derived Bisindole Alkaloid (R)-6'-Debromohamacanthin B as a Dual-Acting Anti-Pathogenic Agent that Targets <i>Pseudomonas aeruginosa</i> Virulence, Biofilm Formation, and Host Immune Responses |
| topic | Bacteriology pseudomonas aeruginosa anti-pathogenic therapy Quorum sensing inhibition anti-biofilm host immune modulation |