Validation of newly constructed 5JI4 phage library based on the predicted ES scores.

Validation of newly constructed 5JI4 phage library based on the predicted ES scores.

<p><b>A.</b> Visualization of 5JI4’s ES scores, where the positions scoring below the median are set to zero. The randomization regions are colored with light green. <b>B.</b> 5JI4 structure with randomized regions highlighted in green. <b>C.</b> Summary of...

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Bibliographic Details
Main Author: Fei Cai (43088) (author)
Other Authors: Yuehua Wei (1515808) (author), Daniel Kirchhofer (769756) (author), Andrew Chang (578485) (author), Yingnan Zhang (270437) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
yeast surface display
naturally occurring disulfide
natural language understanding
high accuracy across
de novo </
attractive therapeutic modalities
alanine scanning experiment
good folding properties
enhanced folding efficiency
highly functional libraries
findings could pave
exhibiting highly stable
work advances peptide
utilizing multiple dcps
div >< p
>- designed hcp
discovering peptide therapeutics
original library design
peptide scaffolds played
libraries could
spontaneous folding
stable topology
library design
peptide scaffolds
developing therapeutics
based therapeutics
techniques used
scale dataset
robust platform
rapid prediction
prediction model
poor chemical
physical stability
model based
like scaffolds
key residues
insights gained
first generated
emerging modality
either agonize
efficient development
crucial role
broad range
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Summary:<p><b>A.</b> Visualization of 5JI4’s ES scores, where the positions scoring below the median are set to zero. The randomization regions are colored with light green. <b>B.</b> 5JI4 structure with randomized regions highlighted in green. <b>C.</b> Summary of the hit numbers achieved by the 5JI4 phage library for ten panning campaigns.</p>

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