Mapping of signature sites on the three-dimensional structure of gp120 shows clustering around the CD4-binding site.

Mapping of signature sites on the three-dimensional structure of gp120 shows clustering around the CD4-binding site.

<p>A ribbon representation of the crystal structure from the JRFL gp120 molecule (grey) bound to CD4 molecule (green) (PDBID: 2B4C). The CD4 binding site is highlighted in transparent green while signature sites 283, 343, 362, 389, 429, 465 and 471 are all depicted as <i>red</i> sp...

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Bibliographic Details
Main Author: Damien C. Tully (178488) (author)
Other Authors: Colin B. Ogilvie (2734831) (author), Rebecca E. Batorsky (2734837) (author), David J. Bean (2734822) (author), Karen A. Power (177172) (author), Musie Ghebremichael (263742) (author), Hunter E. Bedard (2734840) (author), Adrianne D. Gladden (178756) (author), Aaron M. Seese (2734816) (author), Molly A. Amero (2734828) (author), Kimberly Lane (88596) (author), Graham McGrath (2734819) (author), Suzane B. Bazner (2734825) (author), Jake Tinsley (2734834) (author), Niall J. Lennon (177164) (author), Matthew R. Henn (103220) (author), Zabrina L. Brumme (178788) (author), Philip J. Norris (116608) (author), Eric S. Rosenberg (249126) (author), Kenneth H. Mayer (116219) (author), Heiko Jessen (51152) (author), Sergei L. Kosakovsky Pond (25959) (author), Bruce D. Walker (64224) (author), Marcus Altfeld (10455) (author), Jonathan M. Carlson (117346) (author), Todd M. Allen (177189) (author)
Published: 2016
Subjects:
Biotechnology
Evolutionary Biology
Ecology
Cancer
Infectious Diseases
Virology
Space Science
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
founder viruses
bottleneck
Sexual Transmission Influence
founder virus infections
IDU
CD 4 binding site
HSX founder viruses
MSM
HIV
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Description
Summary:<p>A ribbon representation of the crystal structure from the JRFL gp120 molecule (grey) bound to CD4 molecule (green) (PDBID: 2B4C). The CD4 binding site is highlighted in transparent green while signature sites 283, 343, 362, 389, 429, 465 and 471 are all depicted as <i>red</i> space-filling residues.</p>

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