Male and female mice learn RL+WM behavior task similarly across set sizes and development.
<p>Within the first 200 trials per odor in the novel odor phase, both males (A) and females (D) showed an average performance (fraction correct) significantly above chance (dotted black line at 50%, dotted green line at 70%) in both set size = 2 and set size = 4. Trials are binned as trials pe...
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2024
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| Summary: | <p>Within the first 200 trials per odor in the novel odor phase, both males (A) and females (D) showed an average performance (fraction correct) significantly above chance (dotted black line at 50%, dotted green line at 70%) in both set size = 2 and set size = 4. Trials are binned as trials per stimulus to allow for direct comparison across set sizes. Males showed a small but significant difference in performance between set sizes that grew more pronounced near the end of each session (set size: <i>p</i> = 0.04, set size * time interaction: <i>p</i> = 0.01). Female mice showed a significant interaction between set size and time that favored set size = 4 (set size * time interaction: <i>p</i> = 0.006). (B, E) Performance in males and females showed significant benefit when an odor stimulus was repeated two trials in a row when compared to non-repeated stimulus trials (males: <i>p</i> < 0.0001 in both set sizes; females: <i>p</i> = 0.01 for set size = 2 and <i>p</i> < 0.001 for set size = 4). This effect was observed in both set sizes for both sexes. However, in male mice, while performance in repeat trials was higher in set size = 2 than in set size = 4 (possibly driven by a higher proportion of repeat trials when mice are exposed to 2 odors compared to 4), this relationship was reversed when performance in non-repeat trials was examined (<i>p</i> < 0.0001). (C,F) Mean fraction correct in males and females did not change in sessions across development P30–90, a period that includes both adolescent development and early young adulthood in mice. Lines connect up to three sessions per mouse and show performance for first 200 trials per odor in both set size = 2 and set size = 4 for all sessions analyzed, with dotted lines reflecting 95% confidence intervals. Error bars indicate SEM. Asterisks indicate the result of RM 2-way ANOVA (A,D) and either a paired t-test for within session comparions (repeat with non-repeat in the same set size) or an unpaired t-test and Wilcoxon signed rank test (B,E). *** <i>p</i> < 0.001, ** <i>p</i> < 0.01, * <i>p</i> < 0.05.</p> |
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