GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues.
<p>A. Association of GSRS with the response levels of immune-related pathways across multiple KIRC cohorts. B. Meta-analysis revealed a positive association between GSRS and interferon-γ response levels. C. Association of GSRS with immune cell infiltration levels, highlighting a robust correla...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1852015825056169984 |
|---|---|
| author | Yu Zhang (12946) |
| author2 | Chen Chen (6544) Tianhang Zhu (22421568) Wei Luo (80175) Ranran Zhou (6503195) Wanlong Tan (311259) |
| author2_role | author author author author author |
| author_facet | Yu Zhang (12946) Chen Chen (6544) Tianhang Zhu (22421568) Wei Luo (80175) Ranran Zhou (6503195) Wanlong Tan (311259) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yu Zhang (12946) Chen Chen (6544) Tianhang Zhu (22421568) Wei Luo (80175) Ranran Zhou (6503195) Wanlong Tan (311259) |
| dc.date.none.fl_str_mv | 2025-10-13T17:30:27Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0334104.g008 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/GSRS_was_positively_associated_with_CD8_sup_sup_T_cell_infiltration_levels_in_KIRC_tissues_/30348710 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Marine Biology Cancer Hematology Biological Sciences not elsewhere classified world clinical settings vivo experiments showed spatial transcriptomics revealed pooled hazard ratio offering valuable insights healthy donors (< 05 – 3 gene signature emerged random forest analyses cell exhaustion levels related gene signature div >< p related genes decreased levels cell infiltration 05 ). subsequently incorporated rigorously validated prognostic significance predictive tool positive association pivotal role p </ msigdb database local samples immunotherapeutic response glucocorticoids play glucocorticoid signaling experimentally validating corticosterone treatment confidence interval computational simulations cancer progression 65 ). |
| dc.title.none.fl_str_mv | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>A. Association of GSRS with the response levels of immune-related pathways across multiple KIRC cohorts. B. Meta-analysis revealed a positive association between GSRS and interferon-γ response levels. C. Association of GSRS with immune cell infiltration levels, highlighting a robust correlation with CD8+ T cells infiltration. D. Correlation coefficients of GSRS and CD8+ T cell infiltration across KIRC cohorts. E. Meta-analysis confirms a significant positive association between GSRS and CD8+ T cell infiltration levels. F. Association of GSRS with CD8+ T cell infiltration in the invasive margin, tumor center, and all areas in KIRC samples from the JAVELIN Renal 101 cohort. G. Spatial transcriptomics analysis demonstrates the association of ACADM, ANGPTL4, and NFKB2 with CD8A, as obtained from the CROST database (<a href="https://ngdc.cncb.ac.cn/crost/home" target="_blank">https://ngdc.cncb.ac.cn/crost/home</a>).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_8f3f85c71c27d09e9f4e044cb3bb991e |
| identifier_str_mv | 10.1371/journal.pone.0334104.g008 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30348710 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues.Yu Zhang (12946)Chen Chen (6544)Tianhang Zhu (22421568)Wei Luo (80175)Ranran Zhou (6503195)Wanlong Tan (311259)BiochemistryCell BiologyGeneticsMolecular BiologyPhysiologyImmunologyDevelopmental BiologyMarine BiologyCancerHematologyBiological Sciences not elsewhere classifiedworld clinical settingsvivo experiments showedspatial transcriptomics revealedpooled hazard ratiooffering valuable insightshealthy donors (<05 – 3gene signature emergedrandom forest analysescell exhaustion levelsrelated gene signaturediv >< prelated genesdecreased levelscell infiltration05 ).subsequently incorporatedrigorously validatedprognostic significancepredictive toolpositive associationpivotal rolep </msigdb databaselocal samplesimmunotherapeutic responseglucocorticoids playglucocorticoid signalingexperimentally validatingcorticosterone treatmentconfidence intervalcomputational simulationscancer progression65 ).<p>A. Association of GSRS with the response levels of immune-related pathways across multiple KIRC cohorts. B. Meta-analysis revealed a positive association between GSRS and interferon-γ response levels. C. Association of GSRS with immune cell infiltration levels, highlighting a robust correlation with CD8+ T cells infiltration. D. Correlation coefficients of GSRS and CD8+ T cell infiltration across KIRC cohorts. E. Meta-analysis confirms a significant positive association between GSRS and CD8+ T cell infiltration levels. F. Association of GSRS with CD8+ T cell infiltration in the invasive margin, tumor center, and all areas in KIRC samples from the JAVELIN Renal 101 cohort. G. Spatial transcriptomics analysis demonstrates the association of ACADM, ANGPTL4, and NFKB2 with CD8A, as obtained from the CROST database (<a href="https://ngdc.cncb.ac.cn/crost/home" target="_blank">https://ngdc.cncb.ac.cn/crost/home</a>).</p>2025-10-13T17:30:27ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0334104.g008https://figshare.com/articles/figure/GSRS_was_positively_associated_with_CD8_sup_sup_T_cell_infiltration_levels_in_KIRC_tissues_/30348710CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303487102025-10-13T17:30:27Z |
| spellingShingle | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. Yu Zhang (12946) Biochemistry Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Marine Biology Cancer Hematology Biological Sciences not elsewhere classified world clinical settings vivo experiments showed spatial transcriptomics revealed pooled hazard ratio offering valuable insights healthy donors (< 05 – 3 gene signature emerged random forest analyses cell exhaustion levels related gene signature div >< p related genes decreased levels cell infiltration 05 ). subsequently incorporated rigorously validated prognostic significance predictive tool positive association pivotal role p </ msigdb database local samples immunotherapeutic response glucocorticoids play glucocorticoid signaling experimentally validating corticosterone treatment confidence interval computational simulations cancer progression 65 ). |
| status_str | publishedVersion |
| title | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| title_full | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| title_fullStr | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| title_full_unstemmed | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| title_short | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| title_sort | GSRS was positively associated with CD8<sup>+</sup> T cell infiltration levels in KIRC tissues. |
| topic | Biochemistry Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Marine Biology Cancer Hematology Biological Sciences not elsewhere classified world clinical settings vivo experiments showed spatial transcriptomics revealed pooled hazard ratio offering valuable insights healthy donors (< 05 – 3 gene signature emerged random forest analyses cell exhaustion levels related gene signature div >< p related genes decreased levels cell infiltration 05 ). subsequently incorporated rigorously validated prognostic significance predictive tool positive association pivotal role p </ msigdb database local samples immunotherapeutic response glucocorticoids play glucocorticoid signaling experimentally validating corticosterone treatment confidence interval computational simulations cancer progression 65 ). |