Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay
A nickel-catalyzed intermolecular three-component 1,1-difunctionalization of unactivated alkenes with quinoxaline/naphthoquinone and arylboronic acids via organometallic-radical relay is developed. This efficient protocol provides a new method to access a variety of arylalkanes in moderate to good y...
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2024
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| _version_ | 1852024594254266368 |
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| author | Lingyu Wan (10778518) |
| author2 | Shankun Guo (20404191) Fanglu Sun (20404194) Ke Du (511486) Lizhi Zhang (1358475) Zhengbao Xu (1725133) |
| author2_role | author author author author author |
| author_facet | Lingyu Wan (10778518) Shankun Guo (20404191) Fanglu Sun (20404194) Ke Du (511486) Lizhi Zhang (1358475) Zhengbao Xu (1725133) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lingyu Wan (10778518) Shankun Guo (20404191) Fanglu Sun (20404194) Ke Du (511486) Lizhi Zhang (1358475) Zhengbao Xu (1725133) |
| dc.date.none.fl_str_mv | 2024-12-09T16:33:45Z |
| dc.identifier.none.fl_str_mv | 10.1021/acs.orglett.4c04207.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Nickel-Catalyzed_Three-Component_1_1-Difunctionalization_of_Unactivated_Alkenes_with_Quinoxaline_Naphthoquinone_and_Arylboronic_Acids_via_Organometallic-Radical_Relay/27993816 |
| dc.rights.none.fl_str_mv | CC BY-NC 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biophysics Biochemistry Physiology Biotechnology Mental Health Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified functionalized benzylic radicals efficient protocol provides broad substrate scope catalyzed intermolecular three catalyzed three unactivated alkenes radical relay new method good yields |
| dc.title.none.fl_str_mv | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | A nickel-catalyzed intermolecular three-component 1,1-difunctionalization of unactivated alkenes with quinoxaline/naphthoquinone and arylboronic acids via organometallic-radical relay is developed. This efficient protocol provides a new method to access a variety of arylalkanes in moderate to good yields with a broad substrate scope and excellent functional group tolerance. The mechanistic studies provide insights into the mechanism and origin of chemo- and regioselectivity as well as confirm the generation of functionalized benzylic radicals. |
| eu_rights_str_mv | openAccess |
| id | Manara_8fa17d27238e00a69052abf9f56201af |
| identifier_str_mv | 10.1021/acs.orglett.4c04207.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27993816 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY-NC 4.0 |
| spelling | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical RelayLingyu Wan (10778518)Shankun Guo (20404191)Fanglu Sun (20404194)Ke Du (511486)Lizhi Zhang (1358475)Zhengbao Xu (1725133)BiophysicsBiochemistryPhysiologyBiotechnologyMental HealthInfectious DiseasesEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedfunctionalized benzylic radicalsefficient protocol providesbroad substrate scopecatalyzed intermolecular threecatalyzed threeunactivated alkenesradical relaynew methodgood yieldsA nickel-catalyzed intermolecular three-component 1,1-difunctionalization of unactivated alkenes with quinoxaline/naphthoquinone and arylboronic acids via organometallic-radical relay is developed. This efficient protocol provides a new method to access a variety of arylalkanes in moderate to good yields with a broad substrate scope and excellent functional group tolerance. The mechanistic studies provide insights into the mechanism and origin of chemo- and regioselectivity as well as confirm the generation of functionalized benzylic radicals.2024-12-09T16:33:45ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1021/acs.orglett.4c04207.s002https://figshare.com/articles/dataset/Nickel-Catalyzed_Three-Component_1_1-Difunctionalization_of_Unactivated_Alkenes_with_Quinoxaline_Naphthoquinone_and_Arylboronic_Acids_via_Organometallic-Radical_Relay/27993816CC BY-NC 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279938162024-12-09T16:33:45Z |
| spellingShingle | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay Lingyu Wan (10778518) Biophysics Biochemistry Physiology Biotechnology Mental Health Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified functionalized benzylic radicals efficient protocol provides broad substrate scope catalyzed intermolecular three catalyzed three unactivated alkenes radical relay new method good yields |
| status_str | publishedVersion |
| title | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| title_full | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| title_fullStr | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| title_full_unstemmed | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| title_short | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| title_sort | Nickel-Catalyzed Three-Component 1,1-Difunctionalization of Unactivated Alkenes with Quinoxaline/Naphthoquinone and Arylboronic Acids via Organometallic-Radical Relay |
| topic | Biophysics Biochemistry Physiology Biotechnology Mental Health Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified functionalized benzylic radicals efficient protocol provides broad substrate scope catalyzed intermolecular three catalyzed three unactivated alkenes radical relay new method good yields |