Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx
Background/objectives<p>The complex interplay between sarcoidosis and COVID-19 remains an important area of research, since COVID-19 leads to long-term changes in the immune system. However, COVID-19 is often followed by autoimmune diseases, including newly manifesting sarcoidosis. The goal of...
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2025
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| _version_ | 1849927636550156288 |
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| author | Anna Starshinova (22571846) |
| author2 | Igor Kudryavtsev (5741774) Artem Rubinstein (22679072) Tatiana Akisheva (22679075) Alexey Golovkin (6178088) Zoia Korobova (14593420) Anastasia Kulpina (22679078) Dmitry Kudlay (22571849) |
| author2_role | author author author author author author author |
| author_facet | Anna Starshinova (22571846) Igor Kudryavtsev (5741774) Artem Rubinstein (22679072) Tatiana Akisheva (22679075) Alexey Golovkin (6178088) Zoia Korobova (14593420) Anastasia Kulpina (22679078) Dmitry Kudlay (22571849) |
| author_role | author |
| dc.creator.none.fl_str_mv | Anna Starshinova (22571846) Igor Kudryavtsev (5741774) Artem Rubinstein (22679072) Tatiana Akisheva (22679075) Alexey Golovkin (6178088) Zoia Korobova (14593420) Anastasia Kulpina (22679078) Dmitry Kudlay (22571849) |
| dc.date.none.fl_str_mv | 2025-11-25T06:15:49Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2025.1614461.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_1_Immune_responses_in_pulmonary_sarcoidosis_following_COVID-19_docx/30703736 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetic Immunology autoimmunity granulomatous diseases follicular Th cells post-COVID-19 pathogenesis sarcoidosis Th subsets Th17 |
| dc.title.none.fl_str_mv | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background/objectives<p>The complex interplay between sarcoidosis and COVID-19 remains an important area of research, since COVID-19 leads to long-term changes in the immune system. However, COVID-19 is often followed by autoimmune diseases, including newly manifesting sarcoidosis. The goal of this study is to characterize CD4+ T cell subsets, playing a pivotal role in the regulation of innate and adaptive immunity, in the peripheral blood of patients with sarcoidosis after COVID-19.</p>Methods<p>The peripheral blood samples from patients with sarcoidosis (n = 61) were studied. We divided patients into two distinct groups: sarcoidosis patients with no history of COVID-19 (n= 30) and COVID-19 convalescent patients with sarcoidosis within 12–24 weeks after recovery (n = 31). Healthy controls (n = 40) were similar in terms of age and sex to patients with sarcoidosis. Immunophenotyping of peripheral blood cells was performed using a ten-color flow cytometry.</p>Results<p>Sarcoidosis patients with COVID-19 history had higher levels of T-helper cells (Th) when compared to COVID-19 naïve patients with sarcoidosis, but lower levels when compared to healthy controls. In COVID-19 convalescent patients with sarcoidosis, we noted higher absolute numbers and percentages of CD45RA–CCR7– and CD45RA+CCR7– cells within Th subset. Among COVID-19 convalescent patients with sarcoidosis we also found higher levels of T helper 1 cells and T helper 2 cells (with CXCR5–CCR6–CXCR3+CCR4– and CXCR5–CCR6–CXCR3–CCR4+ phenotypes, respectively) when compared to other groups. We also noted a statistically significant increase in central memory CXCR5+CCR6–CXCR3– follicular Th cells, as wells as effector memory CXCR5+CCR6–CXCR3– and CXCR5+CCR6+CXCR3– follicular Th cells in both groups of patients with sarcoidosis vs. healthy controls.</p>Conclusions<p>Our study demonstrated Th cells imbalance in patients with sarcoidosis and COVID-19 history. These findings suggest possible clinical and visual progression of chronic lung sarcoidosis in COVID-19 convalescent patients.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_90984427d108adbcdf1e75e4cbd5233a |
| identifier_str_mv | 10.3389/fimmu.2025.1614461.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30703736 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docxAnna Starshinova (22571846)Igor Kudryavtsev (5741774)Artem Rubinstein (22679072)Tatiana Akisheva (22679075)Alexey Golovkin (6178088)Zoia Korobova (14593420)Anastasia Kulpina (22679078)Dmitry Kudlay (22571849)Genetic Immunologyautoimmunitygranulomatous diseasesfollicular Th cellspost-COVID-19pathogenesissarcoidosisTh subsetsTh17Background/objectives<p>The complex interplay between sarcoidosis and COVID-19 remains an important area of research, since COVID-19 leads to long-term changes in the immune system. However, COVID-19 is often followed by autoimmune diseases, including newly manifesting sarcoidosis. The goal of this study is to characterize CD4+ T cell subsets, playing a pivotal role in the regulation of innate and adaptive immunity, in the peripheral blood of patients with sarcoidosis after COVID-19.</p>Methods<p>The peripheral blood samples from patients with sarcoidosis (n = 61) were studied. We divided patients into two distinct groups: sarcoidosis patients with no history of COVID-19 (n= 30) and COVID-19 convalescent patients with sarcoidosis within 12–24 weeks after recovery (n = 31). Healthy controls (n = 40) were similar in terms of age and sex to patients with sarcoidosis. Immunophenotyping of peripheral blood cells was performed using a ten-color flow cytometry.</p>Results<p>Sarcoidosis patients with COVID-19 history had higher levels of T-helper cells (Th) when compared to COVID-19 naïve patients with sarcoidosis, but lower levels when compared to healthy controls. In COVID-19 convalescent patients with sarcoidosis, we noted higher absolute numbers and percentages of CD45RA–CCR7– and CD45RA+CCR7– cells within Th subset. Among COVID-19 convalescent patients with sarcoidosis we also found higher levels of T helper 1 cells and T helper 2 cells (with CXCR5–CCR6–CXCR3+CCR4– and CXCR5–CCR6–CXCR3–CCR4+ phenotypes, respectively) when compared to other groups. We also noted a statistically significant increase in central memory CXCR5+CCR6–CXCR3– follicular Th cells, as wells as effector memory CXCR5+CCR6–CXCR3– and CXCR5+CCR6+CXCR3– follicular Th cells in both groups of patients with sarcoidosis vs. healthy controls.</p>Conclusions<p>Our study demonstrated Th cells imbalance in patients with sarcoidosis and COVID-19 history. These findings suggest possible clinical and visual progression of chronic lung sarcoidosis in COVID-19 convalescent patients.</p>2025-11-25T06:15:49ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fimmu.2025.1614461.s001https://figshare.com/articles/dataset/Table_1_Immune_responses_in_pulmonary_sarcoidosis_following_COVID-19_docx/30703736CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307037362025-11-25T06:15:49Z |
| spellingShingle | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx Anna Starshinova (22571846) Genetic Immunology autoimmunity granulomatous diseases follicular Th cells post-COVID-19 pathogenesis sarcoidosis Th subsets Th17 |
| status_str | publishedVersion |
| title | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| title_full | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| title_fullStr | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| title_full_unstemmed | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| title_short | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| title_sort | Table 1_Immune responses in pulmonary sarcoidosis following COVID-19.docx |
| topic | Genetic Immunology autoimmunity granulomatous diseases follicular Th cells post-COVID-19 pathogenesis sarcoidosis Th subsets Th17 |