Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification

PTEN and RB loss in HGSOC. A, Frequency of loss of PTEN protein expression across HRR-centric subtypes. B, Frequency of loss of RB protein expression across HRR-centric subtypes. C, Impact of RB loss on survival in patients based on H...

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Autor Principal:	Robert L. Hollis (15034814) (author)
Outros autores:	Alison M. Meynert (14956260) (author), Caroline O. Michie (15043392) (author), Tzyvia Rye (4733277) (author), Michael Churchman (15034811) (author), Amelia Hallas-Potts (15043395) (author), Ian Croy (15034823) (author), W. Glenn McCluggage (8775452) (author), Alistair R.W. Williams (15043398) (author), Clare Bartos (15034820) (author), Yasushi Iida (4097272) (author), Aikou Okamoto (14957624) (author), Brian Dougherty (108958) (author), J. Carl Barrett (11900099) (author), Ruth March (73809) (author), Athena Matakidou (15034847) (author), Patricia Roxburgh (14961464) (author), Colin A. Semple (15034853) (author), D. Paul Harkin (14873531) (author), Richard Kennedy (248483) (author), C. Simon Herrington (15034817) (author), Charlie Gourley (15034850) (author)
Publicado:	2025
Subjects:	Cancer Cancer Biology Tumor Biology Therapeutic Research and Development Clinical Research and Trials Gynecological Cancers Ovarian cancer Oncogenes & Tumor Suppressors BRCA family Precision Medicine Translational Research Tumor Microenvironment Immune cells and the microenvironment
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author	Robert L. Hollis (15034814)
author2	Alison M. Meynert (14956260) Caroline O. Michie (15043392) Tzyvia Rye (4733277) Michael Churchman (15034811) Amelia Hallas-Potts (15043395) Ian Croy (15034823) W. Glenn McCluggage (8775452) Alistair R.W. Williams (15043398) Clare Bartos (15034820) Yasushi Iida (4097272) Aikou Okamoto (14957624) Brian Dougherty (108958) J. Carl Barrett (11900099) Ruth March (73809) Athena Matakidou (15034847) Patricia Roxburgh (14961464) Colin A. Semple (15034853) D. Paul Harkin (14873531) Richard Kennedy (248483) C. Simon Herrington (15034817) Charlie Gourley (15034850)
author2_role	author author author author author author author author author author author author author author author author author author author author author
author_facet	Robert L. Hollis (15034814) Alison M. Meynert (14956260) Caroline O. Michie (15043392) Tzyvia Rye (4733277) Michael Churchman (15034811) Amelia Hallas-Potts (15043395) Ian Croy (15034823) W. Glenn McCluggage (8775452) Alistair R.W. Williams (15043398) Clare Bartos (15034820) Yasushi Iida (4097272) Aikou Okamoto (14957624) Brian Dougherty (108958) J. Carl Barrett (11900099) Ruth March (73809) Athena Matakidou (15034847) Patricia Roxburgh (14961464) Colin A. Semple (15034853) D. Paul Harkin (14873531) Richard Kennedy (248483) C. Simon Herrington (15034817) Charlie Gourley (15034850)
author_role	author
dc.creator.none.fl_str_mv	Robert L. Hollis (15034814) Alison M. Meynert (14956260) Caroline O. Michie (15043392) Tzyvia Rye (4733277) Michael Churchman (15034811) Amelia Hallas-Potts (15043395) Ian Croy (15034823) W. Glenn McCluggage (8775452) Alistair R.W. Williams (15043398) Clare Bartos (15034820) Yasushi Iida (4097272) Aikou Okamoto (14957624) Brian Dougherty (108958) J. Carl Barrett (11900099) Ruth March (73809) Athena Matakidou (15034847) Patricia Roxburgh (14961464) Colin A. Semple (15034853) D. Paul Harkin (14873531) Richard Kennedy (248483) C. Simon Herrington (15034817) Charlie Gourley (15034850)
dc.date.none.fl_str_mv	2025-11-25T12:23:23Z
dc.identifier.none.fl_str_mv	10.1158/1078-0432.30705572
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Figure_5_from_Multiomic_Characterization_of_High-Grade_Serous_Ovarian_Carcinoma_Enables_High-Resolution_Patient_Stratification/30705572
dc.rights.none.fl_str_mv	CC BY info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Cancer Cancer Biology Tumor Biology Therapeutic Research and Development Clinical Research and Trials Gynecological Cancers Ovarian cancer Oncogenes & Tumor Suppressors BRCA family Precision Medicine Translational Research Tumor Microenvironment Immune cells and the microenvironment
dc.title.none.fl_str_mv	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>PTEN and RB loss in HGSOC. <b>A,</b> Frequency of loss of PTEN protein expression across HRR-centric subtypes. <b>B,</b> Frequency of loss of RB protein expression across HRR-centric subtypes. <b>C,</b> Impact of RB loss on survival in patients based on HRR status. Multivariable hazard ratio (mHR) for HRR-ab: RB loss vs. HRR-ab RB-intact = 0.50; 95% CI, 0.30–0.84; mHR for HRRwt/<i>CCNE1</i>g: RB loss vs. HRRwt/<i>CCNE1</i>g: RB-intact = 0.71; 95% CI, 0.48–1.06. <i>BRCA2</i>m, <i>BRCA2</i> mutant; <i>BRCA1</i>m, <i>BRCA1</i> mutant; <i>EMSY</i>-overxp; overexpression of <i>EMSY</i>; nBRCA-HRRm, non-<i>BRCA1</i>/<i>2</i> HRR gene mutation; <i>CCNE1</i>g, gain of <i>CCNE1</i>; HRRwt, non-<i>CCNE1</i>g HRR wild-type. HRR-ab, HRR-aberrant: <i>BRCA1</i>m, <i>BRCA2</i>m, <i>EMSY</i>-overxp, or n<i>BRCA</i>-HRRm.</p>
eu_rights_str_mv	openAccess
id	Manara_9293d33ee6bb7379550ef1316dc13606
identifier_str_mv	10.1158/1078-0432.30705572
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30705572
publishDate	2025
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rights_invalid_str_mv	CC BY
spelling	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient StratificationRobert L. Hollis (15034814)Alison M. Meynert (14956260)Caroline O. Michie (15043392)Tzyvia Rye (4733277)Michael Churchman (15034811)Amelia Hallas-Potts (15043395)Ian Croy (15034823)W. Glenn McCluggage (8775452)Alistair R.W. Williams (15043398)Clare Bartos (15034820)Yasushi Iida (4097272)Aikou Okamoto (14957624)Brian Dougherty (108958)J. Carl Barrett (11900099)Ruth March (73809)Athena Matakidou (15034847)Patricia Roxburgh (14961464)Colin A. Semple (15034853)D. Paul Harkin (14873531)Richard Kennedy (248483)C. Simon Herrington (15034817)Charlie Gourley (15034850)CancerCancer BiologyTumor BiologyTherapeutic Research and DevelopmentClinical Research and TrialsGynecological CancersOvarian cancerOncogenes & Tumor SuppressorsBRCA familyPrecision MedicineTranslational ResearchTumor MicroenvironmentImmune cells and the microenvironment<p>PTEN and RB loss in HGSOC. <b>A,</b> Frequency of loss of PTEN protein expression across HRR-centric subtypes. <b>B,</b> Frequency of loss of RB protein expression across HRR-centric subtypes. <b>C,</b> Impact of RB loss on survival in patients based on HRR status. Multivariable hazard ratio (mHR) for HRR-ab: RB loss vs. HRR-ab RB-intact = 0.50; 95% CI, 0.30–0.84; mHR for HRRwt/<i>CCNE1</i>g: RB loss vs. HRRwt/<i>CCNE1</i>g: RB-intact = 0.71; 95% CI, 0.48–1.06. <i>BRCA2</i>m, <i>BRCA2</i> mutant; <i>BRCA1</i>m, <i>BRCA1</i> mutant; <i>EMSY</i>-overxp; overexpression of <i>EMSY</i>; nBRCA-HRRm, non-<i>BRCA1</i>/<i>2</i> HRR gene mutation; <i>CCNE1</i>g, gain of <i>CCNE1</i>; HRRwt, non-<i>CCNE1</i>g HRR wild-type. HRR-ab, HRR-aberrant: <i>BRCA1</i>m, <i>BRCA2</i>m, <i>EMSY</i>-overxp, or n<i>BRCA</i>-HRRm.</p>2025-11-25T12:23:23ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30705572https://figshare.com/articles/figure/Figure_5_from_Multiomic_Characterization_of_High-Grade_Serous_Ovarian_Carcinoma_Enables_High-Resolution_Patient_Stratification/30705572CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307055722025-11-25T12:23:23Z
spellingShingle	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification Robert L. Hollis (15034814) Cancer Cancer Biology Tumor Biology Therapeutic Research and Development Clinical Research and Trials Gynecological Cancers Ovarian cancer Oncogenes & Tumor Suppressors BRCA family Precision Medicine Translational Research Tumor Microenvironment Immune cells and the microenvironment
status_str	publishedVersion
title	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
title_full	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
title_fullStr	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
title_full_unstemmed	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
title_short	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
title_sort	Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification
topic	Cancer Cancer Biology Tumor Biology Therapeutic Research and Development Clinical Research and Trials Gynecological Cancers Ovarian cancer Oncogenes & Tumor Suppressors BRCA family Precision Medicine Translational Research Tumor Microenvironment Immune cells and the microenvironment

Figure 5 from Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification

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