Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx
Introduction<p>Increased mortality after acute and chronic spinal cord injury (SCI) remains a challenge and mandates a better understanding of the factors contributing to survival in these patients. This study investigated whether body mass index (BMI) measured after acute traumatic SCI is ass...
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2025
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| author | Nader Fallah (262105) |
| author2 | Vanessa K. Noonan (7243673) Nancy P. Thorogood (16638987) Brian K. Kwon (8030765) Marcel A. Kopp (3165726) Jan M. Schwab (11770640) |
| author2_role | author author author author author |
| author_facet | Nader Fallah (262105) Vanessa K. Noonan (7243673) Nancy P. Thorogood (16638987) Brian K. Kwon (8030765) Marcel A. Kopp (3165726) Jan M. Schwab (11770640) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nader Fallah (262105) Vanessa K. Noonan (7243673) Nancy P. Thorogood (16638987) Brian K. Kwon (8030765) Marcel A. Kopp (3165726) Jan M. Schwab (11770640) |
| dc.date.none.fl_str_mv | 2025-11-24T12:38:41Z |
| dc.identifier.none.fl_str_mv | 10.3389/fneur.2023.1269030.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Data_Sheet_1_Effect_of_body_mass_index_on_survival_after_spinal_cord_injury_docx/30694577 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Neurology and Neuromuscular Diseases Neurogenetics acute spinal cord injury body mass index mortality risk Charlson comorbidity index injury severity score |
| dc.title.none.fl_str_mv | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Introduction<p>Increased mortality after acute and chronic spinal cord injury (SCI) remains a challenge and mandates a better understanding of the factors contributing to survival in these patients. This study investigated whether body mass index (BMI) measured after acute traumatic SCI is associated with a change in mortality.</p>Methods<p>A prospective longitudinal cohort study was conducted with 742 patients who were admitted to the Acute Spine Unit of the Vancouver General Hospital between 2004 and 2016 with a traumatic SCI. An investigation of the association between BMI on admission and long-term mortality was conducted using classification and regression tree (CART) and generalized additive models (spline curves) from acute care up to 7.7 years after SCI (chronic phase). Multivariable models were adjusted for (i) demographic factors (e.g., age, sex, and Charlson Comorbidity Index) and (ii) injury characteristics (e.g., neurological level and severity and Injury Severity Score).</p>Results<p>After the exclusion of incomplete datasets (n = 602), 643 patients were analyzed, of whom 102 (18.5%) died during a period up to 7.7 years after SCI. CART identified three distinct mortality risk groups: (i) BMI: > 30.5 kg/m<sup>2</sup>, (ii) 17.5–30.5 kg/m<sup>2</sup>, and (iii) < 17.5 kg/m<sup>2</sup>. Mortality was lowest in the high BMI group (BMI > 30.5 kg/m<sup>2</sup>), followed by the middle-weight group (17.5–30.5 kg/m<sup>2</sup>), and was highest in the underweight group (BMI < 17.5 kg/m<sup>2</sup>). High BMI had a mild protective effect against mortality after SCI (hazard ratio 0.28, 95% CI: 0.09–0.88, p = 0.029), concordant with a modest “obesity paradox”. Moreover, being underweight at admission was a significant risk factor for mortality up to 7.7 years after SCI (hazard ratio 5.5, 95% CI: 2.34–13.17, p < 0.001).</p>Discussion<p>Mortality risk (1 month to 7.7 years after SCI) was associated with differences in BMI at admission. Further research is needed to better understand the underlying mechanisms. Given an established association of BMI with metabolic determinants, these results may suggest unknown neuro-metabolic pathways that are crucial for patient survival.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_940fa206385888231f20c832c72dda40 |
| identifier_str_mv | 10.3389/fneur.2023.1269030.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30694577 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docxNader Fallah (262105)Vanessa K. Noonan (7243673)Nancy P. Thorogood (16638987)Brian K. Kwon (8030765)Marcel A. Kopp (3165726)Jan M. Schwab (11770640)Neurology and Neuromuscular DiseasesNeurogeneticsacute spinal cord injurybody mass indexmortality riskCharlson comorbidity indexinjury severity scoreIntroduction<p>Increased mortality after acute and chronic spinal cord injury (SCI) remains a challenge and mandates a better understanding of the factors contributing to survival in these patients. This study investigated whether body mass index (BMI) measured after acute traumatic SCI is associated with a change in mortality.</p>Methods<p>A prospective longitudinal cohort study was conducted with 742 patients who were admitted to the Acute Spine Unit of the Vancouver General Hospital between 2004 and 2016 with a traumatic SCI. An investigation of the association between BMI on admission and long-term mortality was conducted using classification and regression tree (CART) and generalized additive models (spline curves) from acute care up to 7.7 years after SCI (chronic phase). Multivariable models were adjusted for (i) demographic factors (e.g., age, sex, and Charlson Comorbidity Index) and (ii) injury characteristics (e.g., neurological level and severity and Injury Severity Score).</p>Results<p>After the exclusion of incomplete datasets (n = 602), 643 patients were analyzed, of whom 102 (18.5%) died during a period up to 7.7 years after SCI. CART identified three distinct mortality risk groups: (i) BMI: > 30.5 kg/m<sup>2</sup>, (ii) 17.5–30.5 kg/m<sup>2</sup>, and (iii) < 17.5 kg/m<sup>2</sup>. Mortality was lowest in the high BMI group (BMI > 30.5 kg/m<sup>2</sup>), followed by the middle-weight group (17.5–30.5 kg/m<sup>2</sup>), and was highest in the underweight group (BMI < 17.5 kg/m<sup>2</sup>). High BMI had a mild protective effect against mortality after SCI (hazard ratio 0.28, 95% CI: 0.09–0.88, p = 0.029), concordant with a modest “obesity paradox”. Moreover, being underweight at admission was a significant risk factor for mortality up to 7.7 years after SCI (hazard ratio 5.5, 95% CI: 2.34–13.17, p < 0.001).</p>Discussion<p>Mortality risk (1 month to 7.7 years after SCI) was associated with differences in BMI at admission. Further research is needed to better understand the underlying mechanisms. Given an established association of BMI with metabolic determinants, these results may suggest unknown neuro-metabolic pathways that are crucial for patient survival.</p>2025-11-24T12:38:41ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fneur.2023.1269030.s002https://figshare.com/articles/dataset/Data_Sheet_1_Effect_of_body_mass_index_on_survival_after_spinal_cord_injury_docx/30694577CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306945772025-11-24T12:38:41Z |
| spellingShingle | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx Nader Fallah (262105) Neurology and Neuromuscular Diseases Neurogenetics acute spinal cord injury body mass index mortality risk Charlson comorbidity index injury severity score |
| status_str | publishedVersion |
| title | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| title_full | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| title_fullStr | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| title_full_unstemmed | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| title_short | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| title_sort | Data_Sheet_1_Effect of body mass index on survival after spinal cord injury.docx |
| topic | Neurology and Neuromuscular Diseases Neurogenetics acute spinal cord injury body mass index mortality risk Charlson comorbidity index injury severity score |