<b>Molecular Mechanisms of Batai Virus Entry into N2a Cells via Clathrin-Mediated Endocytosis</b>
<p dir="ltr"><a href="" target="_blank">Batai virus</a> (BATV), an arbovirus belonging to the family Peribunyaviridae, has garnered increasing attention due to its broad host range, expanding geographical distribution, and capacity to naturally infect...
Sábháilte in:
| Príomhchruthaitheoir: | |
|---|---|
| Foilsithe / Cruthaithe: |
2025
|
| Ábhair: | |
| Clibeanna: |
Cuir clib leis
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
|
| Achoimre: | <p dir="ltr"><a href="" target="_blank">Batai virus</a> (BATV), an arbovirus belonging to the family Peribunyaviridae, has garnered increasing attention due to its broad host range, expanding geographical distribution, and capacity to naturally infect the mammalian nervous system with potential evolution into more virulent strains. As an enveloped virus, BATV enters host cells via endocytosis, with <a href="" target="_blank">clathrin-mediated endocytosis</a> (CME) representing the most extensively characterized entry mechanism. This study systematically investigated the molecular mechanisms underlying BATV entry into mouse neuroblastoma N2a cells via CME using chemical inhibitors, dominant-negative mutants, and siRNA interference approaches. Our findings demonstrate that BATV utilizes the CME pathway for cellular entry, relying on both early and late endosomes to facilitate internalization and release of the genome. The virus entry process requires the functional cooperation of clathrin, dynamin, and Eps15, followed by trafficking through Rab5-positive early endosomes and Rab7/Rab9-positive late endosomes in an acidification-dependent manner. This comprehensive understanding of BATV entry mechanisms provides a theoretical foundation for developing targeted antiviral strategies and therapeutic interventions against BATV-related neurological diseases.</p> |
|---|