<i>CTSZ</i> SNPs significantly associated with TB severity in Ugandan household contact study cohorts, sorted by ascending <i>p</i>-value.

<i>CTSZ</i> SNPs significantly associated with TB severity in Ugandan household contact study cohorts, sorted by ascending <i>p</i>-value.

<p><b>Included SNPs were significantly associated with Bandim TBScore after Bonferroni correction for multiple comparisons (</b><b><i><i>p</i></i></b> <b>< 0.05). Complete collection of 81 SNPs can be found in </b><a href="...

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Bibliographic Details
Main Author:	Rachel K. Meade (22216529) (author)
Other Authors:	Oyindamola O. Adefisayo (22216532) (author), Marco T. P. Gontijo (22216535) (author), Summer J. Harris (22216538) (author), Charlie J. Pyle (3617798) (author), Kaley M. Wilburn (12060476) (author), Alwyn M. V. Ecker (13184350) (author), Erika J. Hughes (22216541) (author), Paloma D. Garcia (22216544) (author), Joshua Ivie (22216547) (author), Michael L. McHenry (4672672) (author), Penelope H. Benchek (22216550) (author), Harriet Mayanja-Kizza (78637) (author), Jadee L. Neff (22216553) (author), Dennis C. Ko (7147757) (author), Jason E. Stout (9617361) (author), Catherine M. Stein (7359386) (author), Thomas R. Hawn (12261864) (author), David M. Tobin (8843690) (author), Clare M. Smith (8722557) (author)
Published:	2025
Subjects:	Medicine Microbiology Cell Biology Genetics Neuroscience Immunology Cancer Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified recapitulate human phenotypic outcomes vary widely mouse chromosome 2 lead candidate underlying increased bacterial burden identify significant associations placing human ctsz derived tb granulomas genetically diverse mice tb susceptibility locus tb disease severity div >< p tb susceptibility tb severity tb disease ctsz </ conserved ctsz pulmonary inflammation previously mapped ligand 1 known biomarker genotypic variation findings implicate examine patient decreased survival cxcl1 axis cxcl1 ), cathepsin z asymptomatic infection associated macrophages animal models allows identification ablation leads
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