Difference in binding energy between antigen-antibody complex and antigen-receptor complex.

<p>Antigen refers to SARS-CoV-2 spike protein, antibody is LYCoV-1404 neutralizing antibody, and receptor is human ACE2 protein. The left bar plot lists all the mutations and corresponding differences in the binding energy of the antigen-antibody complex over the antigen-receptor complex. Gree...

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Bibliographic Details
Main Author:	Yee Chuen Teoh (21094780) (author)
Other Authors:	Mohammed Sakib Noor (21094783) (author), Sina Aghakhani (21094786) (author), Jack Girton (408770) (author), Guiping Hu (1673215) (author), Ratul Chowdhury (5665457) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Microbiology Genetics Molecular Biology Evolutionary Biology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified single point mutations require massive amounts protein design applications likely variants ), latest circulating kp iterative design cycles human entry receptors explicit biochemical interactions demonstrate three versions commercial antibody ly reduce antibody binding design selective binding 2 spike protein generalizable computational platform v successfully identifies selectively bind ras div >< p selectively bind retaining binding 2 variant computational workflow computational tracking vivo </ viral escape v ’ stochastic sampling rap1a gtp raf kinase pinpoint 20 iteratively evolved integer optimization inspired framework infective strains immune escape escape mechanism dual bait deep learning biosensor proteins based proteinmpnn ace2 receptor
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Difference in binding energy between antigen-antibody complex and antigen-receptor complex.

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