Removal of IKK in microglia does not protect against prion-induced neuronal death in vitro or in vivo.

A Mixed glial cultures were treated for 7 days with NBH or RML homogenates. Glial conditioned media (GCM) was isolated and plated on N2as in 96-well plates and chamber slides for 48 hours. Image created with Biorender.com. B GCM-treated N2as were analyz...

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Autor principal:	Arielle J. D. Hay (15456341) (author)
Altres autors:	Katriana A. Popichak (12093647) (author), Genova Mumford (15456344) (author), Jifeng Bian (354060) (author), Payton Shirley (21568259) (author), Lauren Wolfrath (21568262) (author), Michael Eggers (21568265) (author), Eric M. Nicholson (8262054) (author), Ronald B. Tjalkens (3281031) (author), Mark D. Zabel (15456359) (author), Julie A. Moreno (7647266) (author)
Publicat:	2025
Matèries:	Medicine Microbiology Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Cancer Infectious Diseases iκb kinase complex cellular stress signals irreversible neuronal loss associated behavioral deficits sc </ sup prion disease pathogenesis prion disease early div >< p cellular prion protein inflammatory signaling molecules infected brain homogenates terminal wt mice induced glial inflammation accelerated disease terminal animals protein homeostasis inflammatory cytokines induced transcription accelerated loss prion diseases signaling pathway intracranially infected infected wild infected brain b signaling specific pathology significantly lower significantly increased significantly downregulated poorly understood nuclear factor near ablation microglial survival key regulator kappa b infectious form increased density including pro host protection hippocampal neurons glial cells forms aggregates findings present cell survival associated genes
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Removal of IKK in microglia does not protect against prion-induced neuronal death <i>in vitro</i> or <i>in vivo.</i>

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