Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection.
<p>Loess-smoothed plots showing the relative abundance of viral transcripts in human colonic organoids (HCOs) infected with EBOV or MARV compared to mock-infected controls at 1 and 3dpi. <b>(A)</b> EBOV-infected versus mock-infected HCOs. <b>(B)</b> MARV-infected versus...
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2025
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| _version_ | 1849927641284476928 |
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| author | Elizabeth Y. Flores (22676699) |
| author2 | Adam J. Hume (6107039) Judith Olejnik (367849) Aditya Mithal (22676702) Andrew D’Amico (2248762) MengWei Yang (22676705) Pushpinder Bawa (733756) Feiya Wang (21075016) Aoife K. O’Connell (15462382) Anna Tseng (20843165) Nicholas A. Crossland (5500244) Gustavo Mostoslavsky (110612) Elke Mühlberger (45516) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Elizabeth Y. Flores (22676699) Adam J. Hume (6107039) Judith Olejnik (367849) Aditya Mithal (22676702) Andrew D’Amico (2248762) MengWei Yang (22676705) Pushpinder Bawa (733756) Feiya Wang (21075016) Aoife K. O’Connell (15462382) Anna Tseng (20843165) Nicholas A. Crossland (5500244) Gustavo Mostoslavsky (110612) Elke Mühlberger (45516) |
| author_role | author |
| dc.creator.none.fl_str_mv | Elizabeth Y. Flores (22676699) Adam J. Hume (6107039) Judith Olejnik (367849) Aditya Mithal (22676702) Andrew D’Amico (2248762) MengWei Yang (22676705) Pushpinder Bawa (733756) Feiya Wang (21075016) Aoife K. O’Connell (15462382) Anna Tseng (20843165) Nicholas A. Crossland (5500244) Gustavo Mostoslavsky (110612) Elke Mühlberger (45516) |
| dc.date.none.fl_str_mv | 2025-11-24T18:35:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.ppat.1013698.s005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Viral_transcript_production_in_EBOV-_and_MARV-infected_HCOs_at_1_and_3days_post-infection_/30697745 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor |
| dc.title.none.fl_str_mv | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Loess-smoothed plots showing the relative abundance of viral transcripts in human colonic organoids (HCOs) infected with EBOV or MARV compared to mock-infected controls at 1 and 3dpi. <b>(A)</b> EBOV-infected versus mock-infected HCOs. <b>(B)</b> MARV-infected versus mock-infected HCOs. Data are representative of <i>n</i> = 3 independent infections per condition.</p> <p>(TIF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_99b0933568e944d120a827e23ac7f655 |
| identifier_str_mv | 10.1371/journal.ppat.1013698.s005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30697745 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection.Elizabeth Y. Flores (22676699)Adam J. Hume (6107039)Judith Olejnik (367849)Aditya Mithal (22676702)Andrew D’Amico (2248762)MengWei Yang (22676705)Pushpinder Bawa (733756)Feiya Wang (21075016)Aoife K. O’Connell (15462382)Anna Tseng (20843165)Nicholas A. Crossland (5500244)Gustavo Mostoslavsky (110612)Elke Mühlberger (45516)BiochemistryMicrobiologyCell BiologyGeneticsMolecular BiologyPhysiologyBiotechnologyImmunologyCancerMental HealthInfectious DiseasesPlant BiologyVirologyBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedxlink "> gastrointestinalsupport viral replicationproviding mechanistic insightinduced secretory diarrheacolonic epithelial responsesmodel ebola virusmediated ion transporthuman gi pathologyion transportsevere diarrheahuman ipscstimulated genesspecific inductionpowerful systempathogen interactionsmarburg virusjunctional disruptionincluding apicalfilovirus diseasefiloviral diseasedissect hostdelayed viruscolonic organoidscentral contributor<p>Loess-smoothed plots showing the relative abundance of viral transcripts in human colonic organoids (HCOs) infected with EBOV or MARV compared to mock-infected controls at 1 and 3dpi. <b>(A)</b> EBOV-infected versus mock-infected HCOs. <b>(B)</b> MARV-infected versus mock-infected HCOs. Data are representative of <i>n</i> = 3 independent infections per condition.</p> <p>(TIF)</p>2025-11-24T18:35:00ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1013698.s005https://figshare.com/articles/figure/Viral_transcript_production_in_EBOV-_and_MARV-infected_HCOs_at_1_and_3days_post-infection_/30697745CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306977452025-11-24T18:35:00Z |
| spellingShingle | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. Elizabeth Y. Flores (22676699) Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor |
| status_str | publishedVersion |
| title | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| title_full | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| title_fullStr | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| title_full_unstemmed | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| title_short | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| title_sort | Viral transcript production in EBOV- and MARV-infected HCOs at 1 and 3days post-infection. |
| topic | Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor |