Autocrine- and paracrine-signaling modes play reciprocal roles in robust cell-cell communication.

<p>The figure shows the effects of perturbing autocrine- and paracrine-signaling modes in theoretical mutant (TM) systems. <b>[A]</b> The TM-APM (inhibition of autocrine, paracrine, and membrane-exchange signaling) represents the loss-of-function phenotype of experimental FGF/ERK p...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Michael Alexander Ramirez Sierra (20209354) (author)
مؤلفون آخرون:	Thomas R. Sokolowski (20209357) (author)
منشور في:	2024
الموضوعات:	Cell Biology Genetics Developmental Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> understanding specific time window providing quantitative predictions identify parameter sets enabling lineage proportions early mammalian development biophysically realistic fashion intracellular initial conditions driven simulation techniques reproducible icm patterning pre lineage proportions level differentiation arises intracellular gene expression inner cell mass ensures correct epi type icm systems stochastic simulation framework stochastic systems necessary conditions high gene expression heterogeneity stochastic description powered simulation icm specification icm exhibits work offers surprising role seemingly cell robust unfolding remains robust reducing fate purely cell proportioning errors primitive endoderm mouse embryogenesis intercellular signaling inherent stochasticity future exploration fgf4 signaling fate proportioning fate decisions exogenous fgf4 efficiently simulating developmental biology combined action central challenge blastocyst stage based inference autonomous system autonomous mechanisms also provides advancing event adjusted based achieve robust
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الملخص:	<p>The figure shows the effects of perturbing autocrine- and paracrine-signaling modes in theoretical mutant (TM) systems. <b>[A]</b> The TM-APM (inhibition of autocrine, paracrine, and membrane-exchange signaling) represents the loss-of-function phenotype of experimental FGF/ERK pathway mutants. <b>[B, C]</b> The complementary TM-A and TM-PM portray the importance of individual feedback modes (paracrine plus membrane exchange and autocrine signaling only, respectively; see also inset text). Solid lines represent mean and standard deviation values (<i>μ</i> and <i>σ</i>) for a given TM; dashed lines represent <i>μ</i> and <i>σ</i> for the inferred-theoretical wild-type (ITWT). <b>[D]</b> Cell-lineage allocation at the 48 h time point. All TMs are compared against the (ITWT). For all compared systems, statistics were calculated from 1000 independent simulation runs. Colors represent different cell fates: UND (olive); EPI (blue); PRE (orange).</p>

Autocrine- and paracrine-signaling modes play reciprocal roles in robust cell-cell communication.

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