Phenotype frequency and complementation for additional novel DY alleles.

<p>A) Phenotype frequency for all mutants identified. Clutches/fish for each mutant: c897:11/634, c898: 8/456, c899: 6/405, c900: NA, c901: 9/701, c902: 5/161, c903: 9/627, c904: 5/398, c905: 6/529, c907: 8/589, c908: 4/399, c909: 7/566, c910: 7/541, c911: 5/534, c912: 7/534, c913: 4/228, c914...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	McKenna Feltes (11242085) (author)
مؤلفون آخرون:	Aleksey V. Zimin (8363328) (author), Sofia Angel (21714119) (author), Nainika Pansari (21714122) (author), Monica R. Hensley (3133671) (author), Jennifer L. Anderson (15991713) (author), Meng-Chieh Shen (4608190) (author), Mackenzie Klemek (21714125) (author), Yi Shen (152956) (author), Vighnesh S. Ginde (21714128) (author), Hannah Kozan (21714131) (author), Nhan V. Le (21714134) (author), Vivian P. Truong (21714137) (author), Meredith H. Wilson (6816489) (author), Steven L. Salzberg (8363331) (author), Steven A. Farber (9217109) (author)
منشور في:	2025
الموضوعات:	Medicine Microbiology Genetics Neuroscience Evolutionary Biology Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified supports positional cloning method using mutants forward genetic screening allelic frequency calculations whereswalker correctly mapped sequencing approach based previously unappreciated apob previously published mutation div >< p sequencing algorithm powerful approach describe whereswalker slc3a2a </ potential candidates mttp </ modifying locus mia2 </ lipoprotein metabolism key step gene causing drastically reduces assign functions 1 </
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الوصف
الملخص:	<p>A) Phenotype frequency for all mutants identified. Clutches/fish for each mutant: c897:11/634, c898: 8/456, c899: 6/405, c900: NA, c901: 9/701, c902: 5/161, c903: 9/627, c904: 5/398, c905: 6/529, c907: 8/589, c908: 4/399, c909: 7/566, c910: 7/541, c911: 5/534, c912: 7/534, c913: 4/228, c914: 4/218, c917: 5/389, c918: 17/1495, c919: 1/47, c920: 2/199, c923: 7/417, c924: 3/151, c952: 6/304, c926: 2/194, c929: 4/364, c930: 4/400, c931: 7/650. Bars represent mean ± standard deviation. Dashed line indicates the expected frequency of 0.25. B-E) Representative images for 7 additional mutants that fail to complement known dark yolk loci, including 3 <i>mttp</i> (B), 2 <i>dgat2</i> (C), 1 <i>mia2</i> (D), and 1 <i>apobb.1</i> (E) alleles. Representative wild-type (wt) and mutant (mut) yolk phenotypes are shown. Animal age is noted. Phenotype frequency is reported as mean ± standard deviation. <i>bigbend</i>: N = 5 clutches, n = 422 animals; <i>guadalupe</i>: N = 6 clutches, n = 598 animals; <i>carlsbad</i>: N = 8 clutches, n = 784 animals; <i>rainier</i>: N = 3 clutches, n = 210 animals; <i>cascade</i>: N = 4 clutches, n = 402 animals; <i>mammoth</i>: N = 3 clutches, n = 282 animals; <i>dune</i>: N = 4 clutches, n = 180 animals;. Scale bar represents 1 mm.</p> <p>(TIFF)</p>

Phenotype frequency and complementation for additional novel DY alleles.

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