Biocatalytic Efficient and Enantiocomplementary Synthesis of 3‑Hydroxy-3-hydroxymethyloxindoles by Combining Halohydrin Dehalogenase and Epoxide Hydrolase

Enantiopure 3-hydroxyoxindoles are one class of basic functional molecules that hold particular interest in medicinal chemistry and drug discovery due to their diverse pharmacological properties. While many chemical methods have been developed for producing these molecules, there remains a continuou...

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Bibliographic Details
Main Author:	Run-Ping Miao (17118351) (author)
Other Authors:	Hai-Xia Zhang (527120) (author), Kui-De Lu (20494784) (author), Tong-Qiu Lu (20494787) (author), Hui-Hui Wang (830267) (author), Yong-Zheng Chen (5155187) (author), Nan-Wei Wan (5330597) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Pharmacology Biotechnology Immunology Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified many chemical methods hold particular interest drug discovery due diverse pharmacological properties catalyzed kinetic resolution catalyzed enantiospecific hydrolysis residual enantiopure spiro enzyme biocatalytic platform biocatalytic platform involves combining halohydrin dehalogenase basic functional molecules 3 ‑ hydroxy biocatalytic platform halohydrin dehalogenase racemic spiro useful transformations synthesized stereoselectively preparative synthesis optical purities one class novel dual medicinal chemistry high yields greener approaches epoxide hydrolase enantiocomplementary synthesis continuous demand chiral products chiral 3 biocatalytic efficient 50 %)
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Biocatalytic Efficient and Enantiocomplementary Synthesis of 3‑Hydroxy-3-hydroxymethyloxindoles by Combining Halohydrin Dehalogenase and Epoxide Hydrolase

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