First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity

The incorporation of silicon bioisosteres into pharmacological structures has been used as a strategy to improve the therapeutic potential of drugs. However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six anal...

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Bibliographic Details
Main Author: Julian Loureiro (20357035) (author)
Other Authors: Samuel Seoane (1695694) (author), Ivo E. Sampaio-Dias (6293594) (author), Carole Peluso-Iltis (236527) (author), Thierry Guiberteau (5250623) (author), Beatriz Brito (3447149) (author), Carlos Gregorio (17320180) (author), Román Pérez-Fernández (1695700) (author), Natacha Rochel (225991) (author), Antonio Mouriño (1451062) (author), José E. Rodríguez-Borges (7148444) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Medicine
Cell Biology
Molecular Biology
Developmental Biology
Cancer
Computational Biology
Chemical Sciences not elsewhere classified
vdr active conformation
ligand binding domain
containing vdr ligands
containing side chains
natural hormone 1
side chain
transcriptional activity
therapeutic potential
structural analysis
silicon bioisosteres
silicon atom
secosteroidal silicon
pharmacological structures
lythgoe diol
dihydroxyvitamin d3
crystal structures
complexes formed
c25 isostere
biological activity
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