PLS-DA regression model from untargeted metabolomics of serum samples from children infected with dengue and controls.

PLS-DA regression model from untargeted metabolomics of serum samples from children infected with dengue and controls.

<p><b>A.</b> PLS-DA 2D Score plot exhibiting a tendence of separation between groups. <b>B.</b> Cross-validation of PLS-DA shows a Q2 of 0.7 for the regression model. <b>C.</b> VIP scores show a metabolite panel with 15 <i>m/z</i> with differenti...

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Detalhes bibliográficos
Autor principal:	Ricardo E. Correa Fierro (22676430) (author)
Outros Autores:	Noroska Gabriela Mogollón Salazar (22676433) (author), Washington B. Cárdenas (3213597) (author), Evencio Joel Medina-Villamizar (22676436) (author), Jefferson Pastuña-Fasso (22676439) (author), Melanie Ochoa-Ocampo (21222826) (author), Giovanna Morán-Marcillo (22676442) (author), Mary Ernestina Regato Arrata (22676445) (author), Mildred Zambrano (16641645) (author), Joyce Andrade (16641648) (author), Juan Chang (8280894) (author), Saurabh Mehta (367781) (author), Fernanda Bertuccez Cordeiro (16641642) (author)
Publicado em:	2025
Assuntos:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Cancer Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified receiver operating characteristic highest predictive power faster patient screening component 5 showing complex immune response serum lipid metabolome evaluate biomarker performance denv ), triggers serum lipidomics profiling new diagnostic tools div >< p disproportionately affects children assess group separation pediatric dengue fever dengue virus infection denv infected group dengue virus dengue fever lipid metabolism diagnostic methods diagnosis tools dengue research biomarker potential biomarker discovery z </ subtropical regions metabolic alterations may contribute mass spectrometry key role glycerol lipids fatty acids despite advancements curve analysis adolescents infected 68345 ). 15 ).
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