The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency.

The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency.

<p><i>(a)</i> Schematic of stimulation with electric field vector. <i>(b)</i> Mean LTP in the proximal stratum radiatum decreases with lower stimulation frequency; the induced LTP for 10 Hz rMS is in agreement with experimental data from Lenz (2015). <i>(c) - (h)&...

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Bibliografske podrobnosti
Glavni avtor: Nicholas Hananeia (22683665) (author)
Drugi avtorji: Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Izdano: 2025
Teme:
Medicine
Cell Biology
Neuroscience
Physiology
Space Science
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
results :</ b
previous experimental studies
objective :</ b
methods :</ b
like cellular effects
conclusion :</ b
background :</ b
strongly distance dependent
scale modeling tools
repetitive magnetic stimulation
biophysical neuronal models
1 hz protocols
successfully modelled plasticity
induced synaptic plasticity
dependent plasticity model
plasticity model
dependent spatio
scale modelling
burst stimulation
5 hz
plasticity amplitude
distal plasticity
term potentiation
term changes
temporal resolution
temporal changes
rms ).
previously established
parameter screening
neurons stimulated
neuronal dendrites
modelling framework
mechanisms behind
low sensitivity
high spatio
fully understood
detailed prediction
dendritic spikes
comprehensive module
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Opis
Izvleček:<p><i>(a)</i> Schematic of stimulation with electric field vector. <i>(b)</i> Mean LTP in the proximal stratum radiatum decreases with lower stimulation frequency; the induced LTP for 10 Hz rMS is in agreement with experimental data from Lenz (2015). <i>(c) - (h)</i> Induction of LTP from 900 pulse rMS protocol at various frequencies. Strong LTP is only seen in the proximal dendrites, with LTP in the stratum radiatum rapidly decreasing with lower frequency.</p>

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