The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency.
<p><i>(a)</i> Schematic of stimulation with electric field vector. <i>(b)</i> Mean LTP in the proximal stratum radiatum decreases with lower stimulation frequency; the induced LTP for 10 Hz rMS is in agreement with experimental data from Lenz (2015). <i>(c) - (h)&...
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2025
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| _version_ | 1849927626278305792 |
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| author | Nicholas Hananeia (22683665) |
| author2 | Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author2_role | author author author author author author |
| author_facet | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| dc.date.none.fl_str_mv | 2025-11-25T18:42:05Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1012295.g003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/The_modelling_framework_for_synaptic_plasticity_replicates_proximal_LTP_induced_by_10_Hz_rMS_protocol_and_predicts_increasing_LTP_with_higher_stimulation_frequency_/30715019 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| dc.title.none.fl_str_mv | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><i>(a)</i> Schematic of stimulation with electric field vector. <i>(b)</i> Mean LTP in the proximal stratum radiatum decreases with lower stimulation frequency; the induced LTP for 10 Hz rMS is in agreement with experimental data from Lenz (2015). <i>(c) - (h)</i> Induction of LTP from 900 pulse rMS protocol at various frequencies. Strong LTP is only seen in the proximal dendrites, with LTP in the stratum radiatum rapidly decreasing with lower frequency.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_9f8e6d3707ac69e8c15c2a7439d469ed |
| identifier_str_mv | 10.1371/journal.pcbi.1012295.g003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30715019 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency.Nicholas Hananeia (22683665)Christian Ebner (1276467)Christos Galanis (15210328)Hermann Cuntz (32618)Alexander Opitz (295799)Andreas Vlachos (47497)Peter Jedlicka (179938)MedicineCell BiologyNeurosciencePhysiologySpace ScienceBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedresults :</ bprevious experimental studiesobjective :</ bmethods :</ blike cellular effectsconclusion :</ bbackground :</ bstrongly distance dependentscale modeling toolsrepetitive magnetic stimulationbiophysical neuronal models1 hz protocolssuccessfully modelled plasticityinduced synaptic plasticitydependent plasticity modelplasticity modeldependent spatioscale modellingburst stimulation5 hzplasticity amplitudedistal plasticityterm potentiationterm changestemporal resolutiontemporal changesrms ).previously establishedparameter screeningneurons stimulatedneuronal dendritesmodelling frameworkmechanisms behindlow sensitivityhigh spatiofully understooddetailed predictiondendritic spikescomprehensive module<p><i>(a)</i> Schematic of stimulation with electric field vector. <i>(b)</i> Mean LTP in the proximal stratum radiatum decreases with lower stimulation frequency; the induced LTP for 10 Hz rMS is in agreement with experimental data from Lenz (2015). <i>(c) - (h)</i> Induction of LTP from 900 pulse rMS protocol at various frequencies. Strong LTP is only seen in the proximal dendrites, with LTP in the stratum radiatum rapidly decreasing with lower frequency.</p>2025-11-25T18:42:05ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1012295.g003https://figshare.com/articles/figure/The_modelling_framework_for_synaptic_plasticity_replicates_proximal_LTP_induced_by_10_Hz_rMS_protocol_and_predicts_increasing_LTP_with_higher_stimulation_frequency_/30715019CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307150192025-11-25T18:42:05Z |
| spellingShingle | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. Nicholas Hananeia (22683665) Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| status_str | publishedVersion |
| title | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| title_full | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| title_fullStr | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| title_full_unstemmed | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| title_short | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| title_sort | The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. |
| topic | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |