Image 1_Altered tactile abnormalities in children with ASD during tactile processing and recognition revealed by dynamic EEG features.pdf
Introduction<p>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by sensory processing abnormalities, particularly in tactile perception, highlighting the need for objective screening methods beyond current subjective behavioral assessments.</p>Methods<p>...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2025
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| الملخص: | Introduction<p>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by sensory processing abnormalities, particularly in tactile perception, highlighting the need for objective screening methods beyond current subjective behavioral assessments.</p>Methods<p>This study developed a portable electro-tactile stimulation system with EEG to evaluate tactile processing differences in children with ASD (n=36) versus typically developing controls (n=36). </p>Results<p>Revealing significantly reduced ERP amplitudes at key processing stages: P200 at FP2 (F(1,70)=10.82, p=0.0454), N200 at F3 (F(1,70)=58.33, p<0.0001), and P300 at C4 (F(1,70)=45.62, p<0.0001). Topographic analysis identified pronounced group differences (>10ìV) across frontal, central, and parietal regions (F8, FC5/6, CP1/2/5/6, Pz, Oz), with ASD children exhibiting prolonged but less efficient tactile discrimination and compensatory prefrontal activation (FP2 CV: p=0.043). The paradigm demonstrated strong reliability (CV ICC: ASD=0.779, TD=0.729) and achieved 85.2% classification accuracy (AUC=0.91) using ANN, with optimal performance from F8 P300 features (sensitivity=87.5%, specificity=83.7%). </p>Discussion<p>These findings provide an objective, efficient (15-minute) screening method that advances understanding of tactile processing abnormalities in ASD and supports the development of physiological biomarkers for early identification, overcoming limitations of questionnaire-based approaches.</p> |
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