MR of the causal estimates of the effects of genetic predisposition to AD on the risk of psoriasis. (A) Scatter plots of the effects of IVs on the genetic predisposition to AD and the subsequent risk of psoriasis. The slope of the straight lines in different colors indicates the causal estimation in the corresponding methods of MR. Each black dot corresponds to an IV included in MR, whereas the gray bars represent the SD of the estimation of the genetic effect. (B) Forest map of the visualized causal influence of each included SNP on the risk of psoriasis. (C) “Leave-one-out” plots of the causality between AD and psoriasis. (D) Causal impact of AD on the risk of psoriasis visualized as a forest map of the five methods. Abbreviations: MR, Mendelian randomization; AD, atopic dermatitis; IVs, instrument variables; SD, standard deviation.
by: Zixia Wang (840665)
Published: (2025)