Theoretical relationship between time since symptom onset and titers in one infected (red) and three uninfected (blue) individuals.

Theoretical relationship between time since symptom onset and titers in one infected (red) and three uninfected (blue) individuals.

<p>These titers are mapped onto a two-dimensional representation of acute and convalescent titers. Ellipsoids represent the expected distribution of acute and convalescent titers for infected and uninfected individuals while the underlying marginal distribution of these acute titers is present...

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1. Verfasser:	Marco Hamins-Puértolas (15238661) (author)
Weitere Verfasser:	Darunee Buddhari (625855) (author), Henrik Salje (589157) (author), Angkana T. Huang (12262139) (author), Taweewun Hunsawong (798675) (author), Derek A.T. Cummings (14971341) (author), Stefan Fernandez (146590) (author), Aaron Farmer (4288318) (author), Surachai Kaewhiran (22683535) (author), Direk Khampaen (22683538) (author), Anon Srikiatkhachorn (110184) (author), Sopon Iamsirithaworn (260152) (author), Adam Waickman (118668) (author), Stephen J. Thomas (7105673) (author), Timothy Endy (150971) (author), Alan L. Rothman (6835178) (author), Kathryn B. Anderson (6835166) (author), Isabel Rodriguez-Barraquer (233670) (author)
Veröffentlicht:	2025
Schlagworte:	Medicine Biotechnology Ecology Immunology Cancer Science Policy Infectious Diseases Virology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified since many cases linked immunosorbent assay independently utilize information hemagglutination inhibition assay globe &# 8217 currently implemented cut convalescent serum collected 87 &# 8211 82 &# 8211 real world data multiple serological assays infer infection events generate finalized interpretations bayesian mixture model prior standard interpretations pcr confirmed infections jointly model data gold standard ). f1 scores ). hai data consistently direct detection methods gold standard f1 scores infection detection eia ). including data individual assays new model igm data whether individuals transmission potential results provide recently experienced provide insight probabilistic framework population living point approaches pathogen systems kamphaeng phet interpreting results incorporating igg important role higher accuracy first test diagnostic process creating uncertainty combined metric already half 677 pairs
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(A) Estimated intercept for titer boost when acute titers are initially low for each assay.
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