Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
<p>Overexpression of mutant PARP1 promotes activation of the IFNγ signaling pathway. (a, b) A549 lung cancer cells and LLC1 lung cancer cells were transfected with the catalytic mutant Flag-PARP1 (E988) followed by stimulation with IFNγ. The lysates were then subjected to western blot analysis...
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2025
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| _version_ | 1849927638851780608 |
|---|---|
| author | Li-Li Long (14963775) |
| author2 | Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458) |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_facet | Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458) |
| author_role | author |
| dc.creator.none.fl_str_mv | Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458) |
| dc.date.none.fl_str_mv | 2025-11-24T23:01:56Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30700008 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_S3_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700008 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment |
| dc.title.none.fl_str_mv | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Overexpression of mutant PARP1 promotes activation of the IFNγ signaling pathway. (a, b) A549 lung cancer cells and LLC1 lung cancer cells were transfected with the catalytic mutant Flag-PARP1 (E988) followed by stimulation with IFNγ. The lysates were then subjected to western blot analysis for indicated proteins.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_a2052092c572f1cfffcc32173071bffe |
| identifier_str_mv | 10.1158/0008-5472.30700008 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30700008 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung CancerLi-Li Long (14963775)Si-Cong Ma (14963778)Ze-Qin Guo (14963781)Yan-Pei Zhang (14963784)Zhenzhen Fan (14963787)Li-Juan Liu (14963790)Li Liu (12292657)Duan-Duan Han (14963793)Meng-Xin Leng (14963796)Jian Wang (14963799)Xue-Jun Guo (14963802)Jia-Le Tan (14963805)Xiao-Ting Cai (14963808)Yan Lin (14963811)Xinghua Pan (14963814)De-Hua Wu (14963817)Xue Bai (14963820)Zhong-Yi Dong (11855458)CancerTumor BiologyMolecular and Cellular BiologyImmuno-oncologyDNA Damage and RepairDNA repairImmunotherapyCombination immunotherapyLung CancerTumor MicroenvironmentImmune cells and the microenvironment<p>Overexpression of mutant PARP1 promotes activation of the IFNγ signaling pathway. (a, b) A549 lung cancer cells and LLC1 lung cancer cells were transfected with the catalytic mutant Flag-PARP1 (E988) followed by stimulation with IFNγ. The lysates were then subjected to western blot analysis for indicated proteins.</p>2025-11-24T23:01:56ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30700008https://figshare.com/articles/figure/Figure_S3_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700008CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307000082025-11-24T23:01:56Z |
| spellingShingle | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer Li-Li Long (14963775) Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment |
| status_str | publishedVersion |
| title | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_full | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_fullStr | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_full_unstemmed | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_short | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_sort | Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| topic | Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment |