Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

<p>Overexpression of mutant PARP1 promotes activation of the IFNγ signaling pathway. (a, b) A549 lung cancer cells and LLC1 lung cancer cells were transfected with the catalytic mutant Flag-PARP1 (E988) followed by stimulation with IFNγ. The lysates were then subjected to western blot analysis...

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Glavni avtor:	Li-Li Long (14963775) (author)
Drugi avtorji:	Si-Cong Ma (14963778) (author), Ze-Qin Guo (14963781) (author), Yan-Pei Zhang (14963784) (author), Zhenzhen Fan (14963787) (author), Li-Juan Liu (14963790) (author), Li Liu (12292657) (author), Duan-Duan Han (14963793) (author), Meng-Xin Leng (14963796) (author), Jian Wang (14963799) (author), Xue-Jun Guo (14963802) (author), Jia-Le Tan (14963805) (author), Xiao-Ting Cai (14963808) (author), Yan Lin (14963811) (author), Xinghua Pan (14963814) (author), De-Hua Wu (14963817) (author), Xue Bai (14963820) (author), Zhong-Yi Dong (11855458) (author)
Izdano:	2025
Teme:	Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment
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_version_	1849927638851780608
author	Li-Li Long (14963775)
author2	Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458)
author2_role	author author author author author author author author author author author author author author author author author
author_facet	Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458)
author_role	author
dc.creator.none.fl_str_mv	Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458)
dc.date.none.fl_str_mv	2025-11-24T23:01:56Z
dc.identifier.none.fl_str_mv	10.1158/0008-5472.30700008
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Figure_S3_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700008
dc.rights.none.fl_str_mv	CC BY info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment
dc.title.none.fl_str_mv	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>Overexpression of mutant PARP1 promotes activation of the IFNγ signaling pathway. (a, b) A549 lung cancer cells and LLC1 lung cancer cells were transfected with the catalytic mutant Flag-PARP1 (E988) followed by stimulation with IFNγ. The lysates were then subjected to western blot analysis for indicated proteins.</p>
eu_rights_str_mv	openAccess
id	Manara_a2052092c572f1cfffcc32173071bffe
identifier_str_mv	10.1158/0008-5472.30700008
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30700008
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY
spelling	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung CancerLi-Li Long (14963775)Si-Cong Ma (14963778)Ze-Qin Guo (14963781)Yan-Pei Zhang (14963784)Zhenzhen Fan (14963787)Li-Juan Liu (14963790)Li Liu (12292657)Duan-Duan Han (14963793)Meng-Xin Leng (14963796)Jian Wang (14963799)Xue-Jun Guo (14963802)Jia-Le Tan (14963805)Xiao-Ting Cai (14963808)Yan Lin (14963811)Xinghua Pan (14963814)De-Hua Wu (14963817)Xue Bai (14963820)Zhong-Yi Dong (11855458)CancerTumor BiologyMolecular and Cellular BiologyImmuno-oncologyDNA Damage and RepairDNA repairImmunotherapyCombination immunotherapyLung CancerTumor MicroenvironmentImmune cells and the microenvironment<p>Overexpression of mutant PARP1 promotes activation of the IFNγ signaling pathway. (a, b) A549 lung cancer cells and LLC1 lung cancer cells were transfected with the catalytic mutant Flag-PARP1 (E988) followed by stimulation with IFNγ. The lysates were then subjected to western blot analysis for indicated proteins.</p>2025-11-24T23:01:56ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30700008https://figshare.com/articles/figure/Figure_S3_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700008CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307000082025-11-24T23:01:56Z
spellingShingle	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer Li-Li Long (14963775) Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment
status_str	publishedVersion
title	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_full	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_fullStr	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_full_unstemmed	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_short	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_sort	Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
topic	Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment

Figure S3 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

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