Enhanced intrinsic excitability of spinal Calcrl<sup>+</sup> neurons in chronic itch.

Enhanced intrinsic excitability of spinal Calcrl<sup>+</sup> neurons in chronic itch.

<p><b>(A)</b> Representative step depolarization responses from Calcrl<sup>+</sup> neurons in both group. <b>(B)</b> Rheobase measurements revealed hyperexcitability in ACD mice (n = 38 neurons for sham, n = 40 neurons for ACD mice). <b>(C)</b> R...

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Dades bibliogràfiques
Autor principal:	Huifeng Jiao (11537806) (author)
Altres autors:	Qi Dai (196898) (author), Zhaoting Li (5491976) (author), Min Yuan (202757) (author), Guoqun Xu (22633999) (author), Yingxin Tian (489748) (author), Guangyuan Su (22634002) (author), Yu Zhang (12946) (author), Chong Sun (2134873) (author), Shunqi Wang (9677645) (author), Chaolin Ma (7547090) (author), Haili Pan (12404423) (author)
Publicat:	2025
Matèries:	Biophysics Medicine Cell Biology Neuroscience Physiology Biotechnology Developmental Biology Science Policy Infectious Diseases Biological Sciences not elsewhere classified sup >+</ sup spontaneous scratching behaviors providing actionable targets evoked synaptic excitation evoked excitatory transmission div >< p devastating dermatological disorder mechanical itch signaling mechanical itch sensitization mechanical itch pathophysiology reduced inhibitory input chronic itch models chronic itch model allergic contact dermatitis using chemogenetic manipulation neurons undergo hyperexcitability downstream urocortin 3 spinal projection neurons wherein spinal calcrl chronic itch spinal calcrl inhibitory interneurons atopic dermatitis chemogenetic inhibition chemogenetic activation expressing neurons significantly amplified seminal studies present study neural circuitry naïve mice morphological assays like receptor incomplete understanding findings establish electrophysiological approaches dependent circuit critical driver calcitonin receptor behavioral tests
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