(related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions.
<p><b>A)</b> Histogram of stimulus selectivity (positive values: cells prefer rewarded go stimulus; negative values: cells prefer unrewarded no-go stimulus) for pre- and post-learning of the visual discrimination task. Pre: <i>n</i> = 1,147, 10 mice, 0.05 ± 0.02; Post:...
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2025
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| _version_ | 1849927627034329088 |
|---|---|
| author | Lilia Kukovska (22683586) |
| author2 | Katharina A. Wilmes (22683589) Natsumi Y. Homma (22683592) Claudia Clopath (324706) Jasper Poort (22683595) |
| author2_role | author author author author |
| author_facet | Lilia Kukovska (22683586) Katharina A. Wilmes (22683589) Natsumi Y. Homma (22683592) Claudia Clopath (324706) Jasper Poort (22683595) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lilia Kukovska (22683586) Katharina A. Wilmes (22683589) Natsumi Y. Homma (22683592) Claudia Clopath (324706) Jasper Poort (22683595) |
| dc.date.none.fl_str_mv | 2025-11-25T18:37:21Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pbio.3003518.s010 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/_related_to_Fig_5_Effects_of_PV_cell_activation_on_the_activity_of_Pyr_cells_across_the_different_time_windows_and_task_difficulty_conditions_/30714553 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects |
| dc.title.none.fl_str_mv | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>A)</b> Histogram of stimulus selectivity (positive values: cells prefer rewarded go stimulus; negative values: cells prefer unrewarded no-go stimulus) for pre- and post-learning of the visual discrimination task. Pre: <i>n</i> = 1,147, 10 mice, 0.05 ± 0.02; Post: <i>n</i> = 1,467, 9 mice, 0.14 ± 0.02; <i>p</i> < 0.002 (Wilcoxon rank-sum test). Median ± SEM. <b>B)</b> Average stimulus response activity at different times, ranging from 0 to 120 ms (laser duration), 120–240, 240–360, 360–480, and 480–600 ms, during the early window stimulation (0–120 ms) when stimulating PV cells with highest laser (control subtracted). Error bars, SEM. <b>C)</b> Average responses of two population of neurons (left panel, Pyr cells; right panel; PV cells) to optogenetic laser illumination at three different levels during the entire stimulus duration (0–2 s). The activity to the visual stimulus of Pyr cells (<i>n</i> = 1,156) is suppressed, whereas PV cells (<i>n</i> = 39) is increased. Shading, SEM. <b>D)</b> Difference in mean visual stimulus-evoked response with PV cell activation (control subtracted), aligned to visual stimulus onset (continuous line). Cells were ordered by their averaged activity at 0–1 s. Color bar range indicates activity, with positive values (blue) for cells increasing their activity and negative values (red) for cells decreasing their activity as a result of laser stimulation. <b>E)</b> is same as D) but for difficult task. <b>F)</b> Average activity response to visual stimulus in the absence (black) and presence (red) of laser stimulation, for the entire (left panel) and the early window condition (right panel). <b>G)</b> is same as F) but for difficult task. In plots D) to G): dashed line at 2 s for the entire window and at 0.12 s for the early window marks the laser stimulation offset; data shown for the highest laser power.</p> <p>(TIFF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_a33688739f5ccd68c57daac86fa3ce3c |
| identifier_str_mv | 10.1371/journal.pbio.3003518.s010 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714553 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions.Lilia Kukovska (22683586)Katharina A. Wilmes (22683589)Natsumi Y. Homma (22683592)Claudia Clopath (324706)Jasper Poort (22683595)BiochemistryNeuroscienceDevelopmental BiologyScience PolicyMental HealthBiological Sciences not elsewhere classifiedxlink "> inhibitionthree major factorsstrong competitive interactionsphoton imaging showedbalanced cortical activityprimary visual cortexsustained v1 activitycombined optogenetic activationv1 cells capturedmoderate pv activationmoderate activationvisual discriminationsexpressing cellsnonlinear activationdependent activationactivation strengthtask difficultystimulus onsetperceptual discriminationdifficult discriminationsdelineates conditionscircuit modelbehavioral effects<p><b>A)</b> Histogram of stimulus selectivity (positive values: cells prefer rewarded go stimulus; negative values: cells prefer unrewarded no-go stimulus) for pre- and post-learning of the visual discrimination task. Pre: <i>n</i> = 1,147, 10 mice, 0.05 ± 0.02; Post: <i>n</i> = 1,467, 9 mice, 0.14 ± 0.02; <i>p</i> < 0.002 (Wilcoxon rank-sum test). Median ± SEM. <b>B)</b> Average stimulus response activity at different times, ranging from 0 to 120 ms (laser duration), 120–240, 240–360, 360–480, and 480–600 ms, during the early window stimulation (0–120 ms) when stimulating PV cells with highest laser (control subtracted). Error bars, SEM. <b>C)</b> Average responses of two population of neurons (left panel, Pyr cells; right panel; PV cells) to optogenetic laser illumination at three different levels during the entire stimulus duration (0–2 s). The activity to the visual stimulus of Pyr cells (<i>n</i> = 1,156) is suppressed, whereas PV cells (<i>n</i> = 39) is increased. Shading, SEM. <b>D)</b> Difference in mean visual stimulus-evoked response with PV cell activation (control subtracted), aligned to visual stimulus onset (continuous line). Cells were ordered by their averaged activity at 0–1 s. Color bar range indicates activity, with positive values (blue) for cells increasing their activity and negative values (red) for cells decreasing their activity as a result of laser stimulation. <b>E)</b> is same as D) but for difficult task. <b>F)</b> Average activity response to visual stimulus in the absence (black) and presence (red) of laser stimulation, for the entire (left panel) and the early window condition (right panel). <b>G)</b> is same as F) but for difficult task. In plots D) to G): dashed line at 2 s for the entire window and at 0.12 s for the early window marks the laser stimulation offset; data shown for the highest laser power.</p> <p>(TIFF)</p>2025-11-25T18:37:21ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pbio.3003518.s010https://figshare.com/articles/figure/_related_to_Fig_5_Effects_of_PV_cell_activation_on_the_activity_of_Pyr_cells_across_the_different_time_windows_and_task_difficulty_conditions_/30714553CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307145532025-11-25T18:37:21Z |
| spellingShingle | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. Lilia Kukovska (22683586) Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects |
| status_str | publishedVersion |
| title | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| title_full | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| title_fullStr | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| title_full_unstemmed | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| title_short | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| title_sort | (related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions. |
| topic | Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects |