Ig-like and Jelly-roll folds.

<p><b>A) IgC2 schematic topology B) Conceptual A and G strands swap comparing Jelly-roll to Ig-like</b> transforming AB and GF loops into straddling loops between Sheets 1 and 2 of the sandwich changing from ABE and GFCC’ in an IgC2 domain to BGE and AFCC’ sheet respectively in wha...

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Bibliographic Details
Main Author:	Caesar Tawfeeq (21087272) (author)
Other Authors:	Jiyao Wang (2121157) (author), Umesh Khaniya (8822018) (author), Thomas Madej (185877) (author), James Song (4570324) (author), Ravinder Abrol (1425607) (author), Philippe Youkharibache (266279) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Biotechnology Immunology Developmental Biology Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified protein engineering around protein coding regions accurate machine learning numbering scheme powers molecular interaction systems current estimates ranging div >< p domain variants constituting systematically recognize ig extended ” architecture common structural signature like domain variants robust fold detection interactomes </ p ig structural proteomes structural variants systems </ domain sharing scheme provides current databases structural proteomes comparative structural extended domains “ ig ig interactomes wide spectrum vascular system systematic annotation straightforward based sheds light remarkable property reliably fold populous fold poorly annotated particular jelly nervous system muscular system much higher labeling mechanism key elements immune system human genome evolutionary analyses diverse topologies classified today cell recognition algorithm implemented >&# 8220
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Ig-like and Jelly-roll folds.

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