Aza-peptide aldehydes and ketones: synthesis and evaluation as human 20S proteasome inhibitors

<p>Aza-peptide aldehydes and ketones were developed as a new class of peptidyl analogues to inhibit the human constitutive (c)20S proteasome as alternative therapeutics to treat multiple myeloma (MM).</p> <p>Eleven new aza-peptide aldehydes and ketones were designed based on their...

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Bibliographic Details
Main Author:	Thomas S. Corrigan (5430191) (author)
Other Authors:	Sarah E. Border (5681051) (author), Leilani M. Lotti Diaz (9279095) (author), Kayla Q. Kasper (9279101) (author), Abigail M. Noonchester (21725895) (author), Rasmiah Amer (21725892) (author), Kayla S. Kucway (21725898) (author), Michael Fleisher (21725901) (author), Joseph P. Fernandez (5070962) (author), Alex R. Lovins (18369796) (author), Ana K. Serrano (18148657) (author), Conor R. Caffrey (113916) (author), Anthony J. O’Donoghue (7206356) (author), Don M. Benson Jr (22444028) (author), Christopher M. Hadad (1336719) (author), Özlem Doğan Ekici (9279107) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Genetics Molecular Biology Pharmacology Biotechnology Ecology Cancer Hematology Chemical Sciences not elsewhere classified Proteasome inhibitor aza-peptide aldehydes aza-peptide ketones anticancer multiple myeloma
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Aza-peptide aldehydes and ketones: synthesis and evaluation as human 20S proteasome inhibitors

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